Since its foundation in 1994, the Case Western Reserve University/Case Medical Center/University Hospitals Center for Aids Research (Case CFAR) has been a center of excellence for both clinical and basic AIDS research. The 174 investigators participating in the Case CFAR draw on resources from the Case Western Reserve University (CWRU) School of Medicine, the Case Medical Center (University Hospitals of Cleveland), MetroHealth Medical Center and the Cleveland Clinic Foundation and the Joint Clinical Research Center (JCRC) in Kampala Uganda. As the only NIH-funded CFAR in the Midwestern United States, the CFAR plays an important role in ensuring that cutting-edge AIDS research and well received community outreach is supported in our region of the country. Major strengths in the Case CFAR include international research, especially with respect to research in tuberculosis and HIV malignancy, microbicides, pathogenesis, virology, clinical trials, and training, at the national and international levels. As the first CFAR to make a major investment in international research, we have been able to expand a highly productive and long-standing (21 year) scientific relationship with Makerere University, Kampala. During the last period of the award there has been substantial investment in sophisticated CFAR core facilities at the Joint Clinical Research Center (JCRC) in Kampala. The Case CFAR has the following Specific Aims which are closely aligned with the aims of the National CFAR program; To provide leadership and strategic planning that promotes and supports outstanding HIV/AIDS research at our participating institutions To establish and maintain laboratory cores that provide expertise, state-of-the-art instrumentation and technologies To support the development of junior faculty interested in HIV/AIDS research through the provision of pilot grant awards and dedicated mentoring To support and create educational and training efforts that encompass the whole range of contemporary HIV/AIDS research To conduct community outreach programs To support our long standing commitment to HIV/AIDS research in Uganda To promote and participate in collaborative research efforts within the national CFAR network.
The HIV/AIDS pandemic is the single largest threat to global public health. The Case CFAR creates a collaborative environment that strongly supports HIV research at CWRU and for our colleagues working in Uganda and in other CFARs in the national network.
|Longenecker, Chris T; Jiang, Ying; Orringer, Carl E et al. (2014) Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection. AIDS 28:969-77|
|Mbonye, Uri; Karn, Jonathan (2014) Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. Virology 454-455:328-39|
|Gibson, Richard M; Meyer, Ashley M; Winner, Dane et al. (2014) Sensitive deep-sequencing-based HIV-1 genotyping assay to simultaneously determine susceptibility to protease, reverse transcriptase, integrase, and maturation inhibitors, as well as HIV-1 coreceptor tropism. Antimicrob Agents Chemother 58:2167-85|
|Chiu, Yen-Ling; Shan, Liang; Huang, Hailiang et al. (2014) Sprouty-2 regulates HIV-specific T cell polyfunctionality. J Clin Invest 124:198-208|
|Mukherjee, Pranab K; Chandra, Jyotsna; Retuerto, Mauricio et al. (2014) Oral mycobiome analysis of HIV-infected patients: identification of Pichia as an antagonist of opportunistic fungi. PLoS Pathog 10:e1003996|
|Chandra, Jyotsna; Pearlman, Eric; Ghannoum, Mahmoud A (2014) Animal models to investigate fungal biofilm formation. Methods Mol Biol 1147:141-57|
|Olvera-García, Gustavo; Espinosa, Enrique; Sieg, Scott F et al. (2014) Cytomegalovirus-specific responses of CD38? memory T cells are skewed towards IFN-? and dissociated from CD154 in HIV-1 infection. AIDS 28:311-6|
|Tabler, Caroline O; Lucera, Mark B; Haqqani, Aiman A et al. (2014) CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. J Virol 88:4976-86|
|Zapanta Rinonos, Serendipity; Rai, Urvashi; Vereb, Sydney et al. (2014) Sequential logic of polarity determination during the haploid-to-diploid transition in Saccharomyces cerevisiae. Eukaryot Cell 13:1393-402|
|Hulgan, Todd; Boger, M Sean; Liao, Diana H et al. (2014) Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial. Mediators Inflamm 2014:803095|
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