The Retrovirology Services Core was established in 2002 and is co-directed by Drs. John Coffin and Bharat Ramratnam. The Core provides essential services to other CFAR cores in diagnosis and monitoring of HIV infection as well as specimen processing and archiving. The Core provides innovative tools for collaborative studies from its special interests in international HIV resistance monitoring, host factors influencing HIV natural history, using advances in stem cell biology to better understand HIV pathogenesis, and studies of immune activation. The Core will pursue four Specific Aims: (1) To provide essential viral assays and HIV monitoring methods, (2) To develop and support innovative retrovirology services along four thematic areas including a) developing and supporting assays for resistance monitoring and phylogenetics of HIV to characterize the molecular epidemiology of drug resistant HIV-1 transmission;b) identifying host factors that that correlate with HIV-1 burden in vivo using proteomic signatures in collaboration with Prevention Sciences Core;c) advancing our understanding of HIV-1 pathogenesis by modeling disease with induced pluripotent stem (iPS) cells in collaboration with the newly established Center for Stem Cell Biology, and d), quantifying levels of immune activation in collaboration with Nutrition, Metabolism and GI Core;(3) To provide training and mentorship to the local and international CFAR community and build technical capacity at international sites with a focus on non-clade-B transmission and drug resistance, and (4) To support the processing, archiving and distribution of virologic specimens. The Retrovirology core maintains the CFAR specimen repository and has >60,000 samples available for collaborative research with all CFAR sites. Services are prioritized to support CFAR developmental grant awardees and junior investigators.

Public Health Relevance

The Retrovirology Services Core provides basic laboratory services to HIV-1 investigators affiliated with the Lifespan/Tufts/Brown CFAR including tests of HIV levels and drug resistance for collaborative studies. The Core provides innovative methods to explore drug resistance and the way HIV causes disease. The Core has a large collection of >60,000 specimens available for research studies.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-RRS-A (J1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Miriam Hospital
United States
Zip Code
Joppa, Meredith C; Rizzo, Christie J; Nieves, Amethys V et al. (2016) Pilot Investigation of the Katie Brown Educational Program: A School-Community Partnership. J Sch Health 86:288-97
Genberg, Becky L; Hogan, Joseph W; Braitstein, Paula (2016) Home testing and counselling with linkage to care. Lancet HIV 3:e244-6
Kwara, Awewura; Enimil, Anthony; Gillani, Fizza S et al. (2016) Pharmacokinetics of First-Line Antituberculosis Drugs Using WHO Revised Dosage in Children With Tuberculosis With and Without HIV Coinfection. J Pediatric Infect Dis Soc 5:356-365
Bloomfield, Gerald S; DeLong, Allison K; Akwanalo, Constantine O et al. (2016) Markers of Atherosclerosis, Clinical Characteristics, and Treatment Patterns in Heart Failure: A Case-Control Study of Middle-Aged Adult Heart Failure Patients in Rural Kenya. Glob Heart 11:97-107
Kohli, Rakhi; Winston, Diana; Sheehan, Heidi et al. (2016) Cholesterol Levels in HIV- and/or HCV-Infected Drug Users Living in Argentina. J Int Assoc Provid AIDS Care 15:400-5
Okafor, Chukwuemeka N; Kelso, Natalie E; Bryant, Vaughn et al. (2016) Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons. Psychol Health Med :1-14
Chan, Philip A; Glynn, Tiffany R; Oldenburg, Catherine E et al. (2016) Implementation of Preexposure Prophylaxis for Human Immunodeficiency Virus Prevention Among Men Who Have Sex With Men at a New England Sexually Transmitted Diseases Clinic. Sex Transm Dis 43:717-723
Mullins, Tanya L Kowalczyk; Zimet, Gregory; Lally, Michelle et al. (2016) Adolescent Human Immunodeficiency Virus Care Providers' Attitudes Toward the Use of Oral Pre-Exposure Prophylaxis in Youth. AIDS Patient Care STDS 30:339-48
Hoffmann, Michael; MacCarthy, Sarah; Batson, Ashley et al. (2016) Barriers along the care cascade of HIV-infected men in a large urban center of Brazil. AIDS Care 28:57-62
Operario, Don; Gamarel, Kristi E; Iwamoto, Mariko et al. (2016) Couples-Focused Prevention Program to Reduce HIV Risk Among Transgender Women and Their Primary Male Partners: Feasibility and Promise of the Couples HIV Intervention Program. AIDS Behav :

Showing the most recent 10 out of 643 publications