To further the overall mission of the Penn CFAR in promoting innovative research into the pathogenesis, prevention and treatment of HIV/AIDS, the broad goals of the Developmental Core (Core B) are to: (1) support new interdisciplinary research directions involving investigators from multiple scientific programs and entities within the Penn CFAR;(2) invest in research initiatives identified as scientific priorities through the CFAR Strategic Planning process;(3) encourage and support the development of young investigators in the area of HIV/AIDS research;(4) provide leadership and mentoring for young investigators, and;(5) promote the entry of investigators established in other areas of study to focus on research questions relevant to HIV/AIDS. In order to achieve these goals, the Developmental Core carries out three Specific Aims: (a) a Pilot Grant awards program that funds up to 6 developmental grants each year, judged based on scientific merit and concordance with the mission of the Developmental Core and strategic priorities of the CFAR;(b) an Education and Mentoring program to provide advice, support and leadership for young investigators to facilitate their transition into independent research careers in HIV/AIDS, and;(c) a series of Workshops and Working Groups designed to bring together investigators from different but potentially interrelated areas to foster interdisciplinary interactions. In the nine years of Developmental projects funded since the Penn CFAR's inception (FY2000-2008), the Core has supported 44 pilot projects that have resulted in significant new knowledge of HIV/AIDS; contributed to the subsequent funding of 26 NIH and multiple non-NIH grants;supported the development of research priorities identified through the CFAR strategic planning process;served as the springboard to independent research careers of junior scientists;and to a significant (6 to 1) return on developmental funding support. In the coming cycle the Developmental Core with its successful pilot grant program, will further develop and enhance our junior investigator mentoring program, and continue to serve as a vehicle for realizing priorities and initiatives critical for the interactive research program on campus.

Public Health Relevance

The Developmental Core enables the Penn CFAR community to pursue new directions in HIV/AIDS research by funding early stage pilot projects involving innovation and new collaborations, and supports emerging investigators both through the pilot grant program and by a program of mentoring and education.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI045008-14
Application #
8377887
Study Section
Special Emphasis Panel (ZAI1-SV-A)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$892,822
Indirect Cost
$324,586
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Moeller, Andrew H; Caro-Quintero, Alejandro; Mjungu, Deus et al. (2016) Cospeciation of gut microbiota with hominids. Science 353:380-2
Jacobson, Jeffrey M; Zheng, Lu; Wilson, Cara C et al. (2016) The Safety and Immunogenicity of an Interleukin-12-Enhanced Multiantigen DNA Vaccine Delivered by Electroporation for the Treatment of HIV-1 Infection. J Acquir Immune Defic Syndr 71:163-71
Enane, Leslie A; Gastañaduy, Paul A; Goldfarb, David M et al. (2016) Impact of Rotavirus Vaccination on Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana. Clin Infect Dis 62 Suppl 2:S168-74
Fedor, Theresa M; Kohler, Hans-Peter; McMahon, James M (2016) Changing attitudes and beliefs towards a woman's right to protect against HIV risk in Malawi. Cult Health Sex 18:435-52
Musselwhite, Laura W; Andrade, Bruno B; Ellenberg, Susan S et al. (2016) Vitamin D, D-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study. EBioMedicine 4:115-23
Dowshen, Nadia; Matone, Meredith; Luan, Xianqun et al. (2016) Behavioral and Health Outcomes for HIV+ Young Transgender Women (YTW) Linked To and Engaged in Medical Care. LGBT Health 3:162-7
Motshoge, Thato; Tawe, Leabaneng; Muthoga, Charles Waithaka et al. (2016) Cytochrome P450 2C8*2 allele in Botswana: Human genetic diversity and public health implications. Acta Trop 157:54-8
Liu, Weimin; Sundararaman, Sesh A; Loy, Dorothy E et al. (2016) Multigenomic Delineation of Plasmodium Species of the Laverania Subgenus Infecting Wild-Living Chimpanzees and Gorillas. Genome Biol Evol 8:1929-39
Song, Jinzhao; Mauk, Michael G; Hackett, Brent A et al. (2016) Instrument-Free Point-of-Care Molecular Detection of Zika Virus. Anal Chem 88:7289-94
Chehoud, Christel; Dryga, Anatoly; Hwang, Young et al. (2016) Transfer of Viral Communities between Human Individuals during Fecal Microbiota Transplantation. MBio 7:e00322

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