The Penn CFAR Clinical Core (Core C) forms the central nexus for clinical, translational and patient sample-based interdisciplinary HIV research conducted by CFAR investigators. Its supports and encourages innovative HIV science conducted in multiple programmatic areas through quick access to a broad range of epidemiologic data and clinical material from HIV infected individuals characterized in detail, identification of HIV infected individuals for recruitment into cross sectional or longitudinal studies, and by providing education, mentoring and overall leadership. To carry out this mission the Clinical Core (1) Maintains an Adult/Adolescent Database comprised of over 3000 patients cared for at four adult HIV practices and one adolescent (behaviorally infected) practice, and a Pediatric Database including longitudinal data on 275 perinatally infected children;(2) Maintains both Adult/Adolescent and Pediatric Specimen Repositories linked to the Databases, and supplies investigators with fresh patient material, including large volumes of cells collected by phlebotomy or apheresis, genital secretions, gastrointestinal lymph tissue, peripheral adipose tissue biopsies and cerebrospinal fluid;(3) Provides consultation in design and execution of clinical/translational studies, and laboratory technician assistance with processing, storage, and shipment of clinical specimens;(4) Provides mentorship to trainees and junior faculty and directs educational activities. These services have evolved over the current funding cycle in response to changing scientific needs, opportunities and research priorities identified through proactive strategic planning, user feedback, and input from internal and external expert advisors. In the coming funding cycle we will further enhance support to HIV/AIDS investigators to meet current needs as well as lead the research agenda based on national and CFAR scientific priorities: We have (a) worked with the City of Philadelphia to make Department of Health data available to investigators to study linkage to and retention in care;(b) developed a web based interface so that CFAR investigators can independently access and download data in the Adult/Adolescent Database, and (c) enhanced the availability of large volumes of high-value PBMCs through procurement of apheresis products. Finally, we will support the CFAR Scientific Working Groups focused on HIV/Hepatitis Co-Infection, HIV/Substance Use and Eradication and Functional Cure through expansion and coordination of services responsive to their scientific agendas.

Public Health Relevance

The Clinical Core of the Penn Center for AIDS Research supports interdisciplinary HIV science by offering investigators access to data on a large cohort of patients with HIV infection, and to patient samples, including blood and other body tissues. The Clinical Core also supports investigators through consultation services, use of the CFAR Clinical Laboratory, and education and mentoring activities

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
2P30AI045008-16
Application #
8697302
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Frye, Margaret; Chae, Sophia (2017) Physical attractiveness and women's HIV risk in rural Malawi. Demogr Res 37:251-294
Reid, Michael J A; Steenhoff, Andrew P; Mannathoko, Naledi et al. (2017) Staphylococcus aureus nasal colonization among HIV-infected adults in Botswana: prevalence and risk factors. AIDS Care 29:961-965
Koenig, H C; Mounzer, K; Daughtridge, G W et al. (2017) Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis. HIV Med 18:412-418
Kelly, Matthew S; Surette, Michael G; Smieja, Marek et al. (2017) The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana. Pediatr Infect Dis J 36:e211-e218
Kim, Dorothy; Hofstaedter, Casey E; Zhao, Chunyu et al. (2017) Optimizing methods and dodging pitfalls in microbiome research. Microbiome 5:52
Pardi, Norbert; Secreto, Anthony J; Shan, Xiaochuan et al. (2017) Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge. Nat Commun 8:14630
Wood, Sarah M; Lee, Susan; Barg, Frances K et al. (2017) Young Transgender Women's Attitudes Toward HIV Pre-exposure Prophylaxis. J Adolesc Health 60:549-555
Li, Shuying S; Kochar, Nidhi K; Elizaga, Marnie et al. (2017) DNA Priming Increases Frequency of T-Cell Responses to a Vesicular Stomatitis Virus HIV Vaccine with Specific Enhancement of CD8+ T-Cell Responses by Interleukin-12 Plasmid DNA. Clin Vaccine Immunol 24:
Kohler, Iliana V; Payne, Collin F; Bandawe, Chiwoza et al. (2017) The Demography of Mental Health Among Mature Adults in a Low-Income, High-HIV-Prevalence Context. Demography 54:1529-1558
Clarke, Erik L; Sundararaman, Sesh A; Seifert, Stephanie N et al. (2017) swga: a primer design toolkit for selective whole genome amplification. Bioinformatics 33:2071-2077

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