The activities of the International Core (Core I) are centered in Botswana, a country that serves as a remarkable success story for confronting the HIV/AIDS epidemic in sub-Saharan Africa. Core I has made impressive advances in performing HIV/AIDS research that is relevant to the people of Botswana and that has advanced knowledge of the global epidemic. Markers of our accomplishments include the large number of NIH and Foundation grants in HIV/AIDS that Core I investigators have secured for their research in Botswana during the current funding cycle, the substantial growth in number and quality of publications, and the success at attaining national and international recognition for their research by junior faculty located at Penn and by junior faculty who are residing fulltime in Botswana as part of the Botswana-UPenn Partnership (BUP) program (an extension of Penn's campus in Botswana). The BUP has robust clinical and educational programs focused on providing care and technical assistance related to HIV and its complications, HIV-TB co-infection, multidrug resistant TB, cervical cancer screening in HIV infected women using the

Public Health Relevance

The Penn CFAR International Core has developed vibrant and highly productive research programs in collaboration with the Government of Botswana and the University of Botswana School of Medicine. The research focuses on HIV and its complications, tuberculosis, screening for cervical cancer in HIV infected women, and use of cell phones to improve health care delivery. The impact is substantial as Penn scientists partner with researchers in country to address some ofthe most pressing issues ofthe HIV/AIDS epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI045008-17
Application #
8847273
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
17
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Krump, Nathan A; Liu, Wei; You, Jianxin (2018) Mechanisms of persistence by small DNA tumor viruses. Curr Opin Virol 32:71-79
Gowda, Charitha; Lott, Stephen; Grigorian, Matthew et al. (2018) Absolute Insurer Denial of Direct-Acting Antiviral Therapy for Hepatitis C: A National Specialty Pharmacy Cohort Study. Open Forum Infect Dis 5:ofy076
Clarke, Erik L; Connell, A Jesse; Six, Emmanuelle et al. (2018) T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency. Genome Med 10:70
Coviello, D M; Lovato, R; Apostol, K et al. (2018) Prevalence of HIV Viral Load Suppression Among Psychiatric Inpatients with Comorbid Substance Use Disorders. Community Ment Health J :
Martei, Yehoda M; Pace, Lydia E; Brock, Jane E et al. (2018) Breast Cancer in Low- and Middle-Income Countries: Why We Need Pathology Capability to Solve This Challenge. Clin Lab Med 38:161-173
Ojikutu, Bisola O; Bogart, Laura M; Higgins-Biddle, Molly et al. (2018) Facilitators and Barriers to Pre-Exposure Prophylaxis (PrEP) Use Among Black Individuals in the United States: Results from the National Survey on HIV in the Black Community (NSHBC). AIDS Behav 22:3576-3587
Martin, Maureen P; Naranbhai, Vivek; Shea, Patrick R et al. (2018) Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest 128:1903-1912
Wood, Sarah; Ratcliffe, Sarah; Gowda, Charitha et al. (2018) Impact of insurance coverage on HIV transmission potential among antiretroviral therapy-treated youth living with HIV. AIDS 32:895-902
Shin, S S; Modongo, C; Zetola, N M et al. (2018) High rates of exposure to tuberculosis patients among HIV-infected health care workers in Botswana. Int J Tuberc Lung Dis 22:366-370
Genn, Leah; Chapman, Jennifer; Okatch, Harriet et al. (2018) Pharmacy Refill Data are Poor Predictors of Virologic Treatment Outcomes in Adolescents with HIV in Botswana. AIDS Behav :

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