The goal of the UNC CFAR Immunology Core is to support HIV research by UNC and affiliated investigators aimed at stemming the HIV pandemic. The Immunology Core will achieve this goal by providing infrastructure, services and leadership to facilitate studies ofthe Immunologic aspects of HIV pathogenesis, therapeutics and diagnostics. Specifically, the Core will provide services including: biospecimen procurement and distribution, flow cytometry, immune function testing, soluble marker testing, mmunogenetic testing and training/education. The Core will promote the use of these services by supporting developmental awardees, assisting with the development of grants and contracts addressing immunologic questions of HIV infection and fostering collaborations with industry for evaluation of novel technologies for the diagnosis and monitoring of HIV infection. The Core's established services as well as methods and tools developed via support of investigators and industry will also be used to support various DAIDS groups (ACTG, HPTN, CHAVI), to build capacity at international sites and to support UNC CFAR initiatives including HIV latency, primary infection and AIDS malignancies. Finally, the Core will actively seek input from these users as well as other internal and external advisors to continually assess and improve Core services. By supporting a broad research agenda including pathogenesis, therapeutics and diagnostics, the Core will be a significant component of the efforts to address the HIV pandemic.

Public Health Relevance

The Immunology Core research plan will impact public health in several ways. The core will provide infrastructure and resources to support studies aimed at: (1) preventing transmission of HIV;(2) improving the diagnosis and monitoring of infected persons;(3) elucidating mechanisms of HIV disease, and;(4) improving therapies for HIV infected persons.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050410-15
Application #
8379679
Study Section
Special Emphasis Panel (ZAI1-ELB-A)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
15
Fiscal Year
2012
Total Cost
$159,153
Indirect Cost
$48,125
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Dumond, J B; Collins, J W; Cottrell, M L et al. (2017) p16INK4a , a Senescence Marker, Influences Tenofovir/Emtricitabine Metabolite Disposition in HIV-Infected Subjects. CPT Pharmacometrics Syst Pharmacol 6:120-127
Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390
Chung, Neo Christopher; Bolton-Moore, Carolyn; Chilengi, Roma et al. (2017) Patient engagement in HIV care and treatment in Zambia, 2004-2014. Trop Med Int Health 22:332-339
Masa, Rainier; Chowa, Gina; Nyirenda, Victor (2017) Prevalence and Predictors of Food Insecurity among People Living with HIV Enrolled in Antiretroviral Therapy and Livelihood Programs in Two Rural Zambian Hospitals. Ecol Food Nutr 56:256-276
Tang, Weiming; Huang, Shujie; Chen, Lei et al. (2017) Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study. Sci Rep 7:45339
Nixon, Daniel E; Bosch, Ronald J; Chan, Ellen S et al. (2017) Effects of atorvastatin on biomarkers of immune activation, inflammation, and lipids in virologically suppressed, human immunodeficiency virus-1-infected individuals with low-density lipoprotein cholesterol <130 mg/dL (AIDS Clinical Trials Group Study A52 J Clin Lipidol 11:61-69
Noorhasan, Marisela; Drozd, Daniel R; Grunfeld, Carl et al. (2017) Associations Between At-Risk Alcohol Use, Substance Use, and Smoking with Lipohypertrophy and Lipoatrophy Among Patients Living with HIV. AIDS Res Hum Retroviruses :
Meade, Christina S; Hobkirk, Andrea L; Towe, Sheri L et al. (2017) Cocaine dependence modulates the effect of HIV infection on brain activation during intertemporal decision making. Drug Alcohol Depend 178:443-451
Rossouw, Theresa; Tucker, Joseph D; van Zyl, Gert U et al. (2017) Barriers to HIV remission research in low- and middle-income countries. J Int AIDS Soc 20:21521
Li, Haochu; Xue, Li; Tucker, Joseph D et al. (2017) Condom use peer norms and self-efficacy as mediators between community engagement and condom use among Chinese men who have sex with men. BMC Public Health 17:641

Showing the most recent 10 out of 1520 publications