The UNC CFAR is a consortium of three Institutions: UNC Chapel Hill, Research Triangle Institute (RTI), and Family Health International (FHl). All three institutions are part of the North Carolina Research Triangle Park, and RTI and FHl have historical links to UNC starting with their inception. The goal of the CFAR is promote the broad sweep of HIV/AIDS research through a variety of mechanisms. The CFAR provides core facilities specifically targeted to the needs of the HIV/AIDS research community. The CFAR Developmental Core supports new research initiatives from junior faculty, faculty new to HIV research, faculty at in-State HBCUs, and researchers at CFAR-linked international sites. The CFAR Developmental Awards program has been expanded by 50% with institutional funds, and this funding is further leveraged in partnership with departments and the CTSA in their developmental awards program. The CFAR sponsors the UNC CFAR HIV Clinical Cohort (UCHCC) database, which plays a central role In managing clinical HIV research activity at UNC, and the UCHCC Is part of the Inter-CFAR CNICS network, with the CNICS Biostatistics and Epidemiology Core now residing at UNC. A major strength of the UNC CFAR is our involvement in international work, with key links to Malawi, South Africa, China, Russia, Central America, and the DRC. These links facilitate international research, capacity building, and provide infrastructure for support of important NIH initiative such as the CHAVI and HPTN. Another important feature of our CFAR is our Clinical Pharmacology and Analytical Chemistry Core, which is unique among CFARs and has become a resource both for other CFARs and for several large NIH initiatives. The CFAR Cores and leadership are supporting four new initiatives: HIV latency and eradication;the IDU epidemic in St. Petersburg, Russia;AIDS malignancies;and HIV and the Criminal Justice System (in partnership with the NC State Department of Corrections). These areas are also supported by working groups, in addition to a long standing working group on Acute HIV Infection (in partnership with the NC State Health Department), and a new working group on Structural Determinants of HIV. The UNC CFAR also engages in a number of outreach programs, including developing a distance-learning program for our In-State HBCUs based on the UNC AIDS Course. In recognition of the importance of the CFAR, we receive significant institutional support including the assignment of space to the CFAR for CFAR investigators. The CFAR has become an essential part of the leadership, infrastructure, and identify of the HIV/AIDS research effort among our membership.

Public Health Relevance

The CFAR is committed to supporting research in treatment, prevention, epidemiology, and pathogenesis as part of an overall effort to change the course of the HIV epidemic both domestically and in the international setting. The CFAR provides infrastructure support for our membership, and leadership both within the membership and within the institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI050410-17
Application #
8708733
Study Section
Special Emphasis Panel (ZAI1-ELB-A (J1))
Program Officer
Namkung, Ann S
Project Start
2001-08-20
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
17
Fiscal Year
2014
Total Cost
$2,628,617
Indirect Cost
$849,998
Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Rutstein, S E; Golin, C E; Wheeler, S B et al. (2016) On the front line of HIV virological monitoring: barriers and facilitators from a provider perspective in resource-limited settings. AIDS Care 28:1-10
Cottrell, Mackenzie L; Yang, Kuo H; Prince, Heather M A et al. (2016) A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine. J Infect Dis 214:55-64
Sin, Sang-Hoon; Kang, Sun Ah; Kim, Yongbaek et al. (2016) Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation. J Virol 90:2150-4
Chen, J; Malone, S; Prince, H M A et al. (2016) Model-Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV-Infected Pregnant Women Supports Standard Dosing in the Third Trimester. CPT Pharmacometrics Syst Pharmacol 5:147-57
Davis, Nicole L; Miller, William C; Hudgens, Michael G et al. (2016) Maternal and Breastmilk Viral Load: Impacts of Adherence on Peripartum HIV Infections Averted-The Breastfeeding, Antiretrovirals, and Nutrition Study. J Acquir Immune Defic Syndr 73:572-580
Davis, Alissa; Meyerson, Beth E; Aghaulor, Blessing et al. (2016) Barriers to health service access among female migrant Ugandan sex workers in Guangzhou, China. Int J Equity Health 15:170
O'Donnell, Julie K; Gaynes, Bradley N; Cole, Stephen R et al. (2016) Ongoing life stressors and suicidal ideation among HIV-infected adults with depression. J Affect Disord 190:322-8
Cottrell, Mackenzie L; Prince, Heather M A; Allmon, Andrew et al. (2016) Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design. J Acquir Immune Defic Syndr 72:498-506
Lancaster, Kathryn E; Go, Vivian F; Lungu, Thandie et al. (2016) Substance use and HIV infection awareness among HIV-infected female sex workers in Lilongwe, Malawi. Int J Drug Policy 30:124-31
Lancaster, Kathryn Elizabeth; Powers, Kimberly A; Lungu, Thandie et al. (2016) The HIV Care Continuum among Female Sex Workers: A Key Population in Lilongwe, Malawi. PLoS One 11:e0147662

Showing the most recent 10 out of 1330 publications