The Vanderbilt-Meharry community benefits from strong programs in HIV/AIDS clinical care, research, and? training. Particular strengths include access to a large, diverse patient population through established clinical? research and outcomes research infrastructures, electronic databases and specimen archives for? translational and outcomes research, accomplished outcomes and epidemiology programs suitable for? studying HIV/AIDS, established HIV/AIDS clinical research programs, strength in human genomics relevant? to HIV, and recent recruitment to Vanderbilt and Meharry of many accomplished HIV investigators who will? expand the scope and impact of HIV research. A clear focus of the Clinical Discovery Core (CDC) is to foster? multidisciplinary, high-impact translational and epidemiology/outcomes HIV research at Vanderbilt and? Meharry. The CDC will build upon existing strengths to continue developing a program in HIV outcomes? research, with an emphasis on training new investigators, collaborations with established investigators, and? the study of racial and gender disparities. A long-term goal is to improve HIV clinical research and training? capacity at Meharry, which includes its historic mission of training people of color to serve the under-served? via care, education, and research. The two primary components of the CDC are The Epidemiology and? Outcomes Unit and The Targeted Research Cohorts Unit. With this structure the CDC is ideally positioned to? foster research that spans the continuum from bench to bedside to community. The CDC will focus particular? effort in three special scientific programs that have great potential for high impact and multidisciplinary? collaboration: 1) International HIV/AIDS Research; 2) Human Genomics Relevant to HIV/AIDS, and 3)? Research in NeuroAIDS. These scientific programs, as well as other CDC activities, will be operationalized? through dynamic, task-oriented working groups. The CDC will greatly accelerate the pace of discovery by all? disciplines focused on HIV/AIDS in the Vanderbilt-Meharry community, and will ultimately improve? understanding regarding pathogenesis, prevention, and treatment of this devastating infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI054999-06
Application #
7676755
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
6
Fiscal Year
2008
Total Cost
$531,699
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Liu, Qi; Li, Chun; Wanga, Valentine et al. (2018) Covariate-adjusted Spearman's rank correlation with probability-scale residuals. Biometrics 74:595-605
Li, Binglan; Verma, Shefali S; Veturi, Yogasudha C et al. (2018) Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. Pac Symp Biocomput 23:448-459
Nicholas, Katherine J; Flaherty, David K; Smith, Rita M et al. (2017) Chronic HIV-1 Infection Impairs Superantigen-Induced Activation of Peripheral CD4+CXCR5+PD-1+ Cells, With Relative Preservation of Recall Antigen-Specific Responses. J Acquir Immune Defic Syndr 74:72-80
Drozd, Daniel R; Kitahata, Mari M; Althoff, Keri N et al. (2017) Increased Risk of Myocardial Infarction in HIV-Infected Individuals in North America Compared With the General Population. J Acquir Immune Defic Syndr 75:568-576
Muzaale, A D; Althoff, K N; Sperati, C J et al. (2017) Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors. Am J Transplant 17:1823-1832
Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Fritz, Cristin Q; Blevins, Meridith; Lindegren, Mary Lou et al. (2017) Comprehensiveness of HIV care provided at global HIV treatment sites in the IeDEA consortium: 2009 and 2014. J Int AIDS Soc 20:20933
Verma, Anurag; Bradford, Yuki; Verma, Shefali S et al. (2017) Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Pharmacogenet Genomics 27:101-111
Koethe, John R; Jenkins, Cathy A; Lau, Bryan et al. (2016) Higher Time-Updated Body Mass Index: Association With Improved CD4+ Cell Recovery on HIV Treatment. J Acquir Immune Defic Syndr 73:197-204
Rebeiro, Peter F; Gange, Stephen J; Horberg, Michael A et al. (2016) Geographic Variations in Retention in Care among HIV-Infected Adults in the United States. PLoS One 11:e0146119

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