Core F The Duke University CFAR Clinical Core (Core F) provides a dynamic, higlily motivated and effective environment for HIV-related clinical studies within the Duke CFAR. In line with the overall mission for a CFAR, this Core provides "value-added" to facilitate patient-oriented research by providing clinical research expertise, regulatory support, access to patient specimens, and community involvement. The Core is responsive to the needs of the investigators within Duke and has aggressively pursued opportunities to expand clinical opportunities in Durham and through international sites. This Core has three specific aims: 1) To facilitate cutting edge patient-oriented research by clinical and laboratory investigators through the development of new Core services responsive to investigator needs and CFAR priorities such as international collaborations, and an enhanced database linked to a specimen repository;2) To catalyze patient-oriented research collaborations between Duke CFAR investigators, especially within CFAR priority areas of HIV pathogenesis and AIDS-associated malignancies, by translating the hypotheses of Duke CFAR investigators into clinical studies, bringing novel clinical observations back to laboratory investigators, facilitating and leading interdisciplinary research teams, and actively participating in CFAR conferences and symposia;3) To attract new investigators into patient-oriented research investigating HIV/AIDS by emphasizing interdisciplinary research efforts, communicating with key partners such as the Duke Global Health Institute and the Duke Comprehensive Cancer Institute, suggesting new collaborations, and recruiting new Duke faculty. Clinical Core accomplishments from the first four years suggest that the Clinical Core will thrive as the centerpiece of patient-oriented research within the CFAR in the next funding cycle, driving the CFAR to realize its scientific priorities.
The Clinical Core provides access and research expertise for laboratory investigators to move from bench to bedside, and facilitates the ability of clinical investigators to bring their observations back to laboratory scientists. The Core also provides the opportunity to perform translational and investigator-initiated research, and assures that all human subjects research is conducted with the highest level of Good Clinical Practice.
|Mkhize, Nonhlanhla N; Durgiah, Raveshni; Ashley, Vicki et al. (2016) Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women. AIDS 30:1005-14|
|Brochhausen, Mathias; Zheng, Jie; Birtwell, David et al. (2016) OBIB-a novel ontology for biobanking. J Biomed Semantics 7:23|
|Kidd, Marie J; Jackson, Katherine J L; Boyd, Scott D et al. (2016) DJ Pairing during VDJ Recombination Shows Positional Biases That Vary among Individuals with Differing IGHD Locus Immunogenotypes. J Immunol 196:1158-64|
|Ramaiya, Megan K; Sullivan, Kristen A; O' Donnell, Karen et al. (2016) A Qualitative Exploration of the Mental Health and Psychosocial Contexts of HIV-Positive Adolescents in Tanzania. PLoS One 11:e0165936|
|Kelly, Matthew S; Crotty, Eric J; Rattan, Mantosh S et al. (2016) Chest Radiographic Findings and Outcomes of Pneumonia Among Children in Botswana. Pediatr Infect Dis J 35:257-62|
|Healy, Zachary R; Murdoch, David M (2016) OMIP-036: Co-inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets. Cytometry A 89:889-892|
|Park, Se Eun; Pak, Gi Deok; Aaby, Peter et al. (2016) The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa. Clin Infect Dis 62 Suppl 1:S23-31|
|Pacek, Lauren R; Sweitzer, Maggie M; McClernon, F Joseph (2016) Non-cigarette tobacco and poly-tobacco use among persons living with HIV drawn from a nationally representative sample. Drug Alcohol Depend 162:251-5|
|Bengtson, Angela M; Pence, Brian W; Gaynes, Bradley N et al. (2016) Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care. J Acquir Immune Defic Syndr 73:482-488|
|Abedini-Nassab, Roozbeh; Joh, Daniel Y; Albarghouthi, Faris et al. (2016) Magnetophoretic transistors in a tri-axial magnetic field. Lab Chip 16:4181-4188|
Showing the most recent 10 out of 390 publications