; The Clinical and Translational Sciences Core (CTSC;Core C) will provide key services to UR investigators to promote collaborative clinical and translational HIV/AIDS research. The objective of the Core is to efficiently provide UR HIV/AIDS investigators direct access to human subjects research, a discipline that can be dauntingly complex and time-consuming for new investigators (including early-stage investigators, investigators new to HIV/AIDS, and basic science HIV/AIDS investigators wishing to conduct translational research). It will do so by leveraging existing infrastructure, resources and expertise, at modest incremental cost, to create broad synergies that can make a major impact on clinical and translational studies. Our experience as a D-CFAR has shown that providing that access to services alone is not necessarily sufficient to encourage new investigators to undertake translational HIV/AIDS projects. This has led us to develop a highly proactive, user-oriented, innovative approach, that includes consultation, advice and even identification and recruitment of study subjects (including data and/or specimens), and will support studies in hard-to-reach populations, by working with community organizations and existing UR infrastructure.
Aim 3 will provide training and education on human subjects research, including community-based studies, and will also conduct outreach to build trusting relationships with communities heavily impacted by HIV/AIDS.
Aim 4 will help to establish interdisciplinary collaborations, and Aim 5 will integrate Core activities with other institutional resources (including the UR CTSI).
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|McMahon, James M; Volpe, Ellen M; Klostermann, Keith et al. (2015) A systematic review of the psychometric properties of the Sexual Relationship Power Scale in HIV/AIDS research. Arch Sex Behav 44:267-94|
|Bobo, Bryan; Phelan, Dana; Rebhahn, Jonathan et al. (2014) Microbubble array diffusion assay for the detection of cell secreted factors. Lab Chip 14:3640-50|
|Liu, Zhi-Ping; Wu, Hulin; Zhu, Jian et al. (2014) Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection. BMC Bioinformatics 15:336|
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|Piekna-Przybylska, Dorota; Sullivan, Mark A; Sharma, Gaurav et al. (2014) U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence. Biochemistry 53:2581-93|
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|Silva, Jharon N; Polesskaya, Oksana; Wei, Helen S et al. (2014) Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity. Microcirculation 21:664-76|
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