; The Clinical and Translational Sciences Core (CTSC;Core C) will provide key services to UR investigators to promote collaborative clinical and translational HIV/AIDS research. The objective of the Core is to efficiently provide UR HIV/AIDS investigators direct access to human subjects research, a discipline that can be dauntingly complex and time-consuming for new investigators (including early-stage investigators, investigators new to HIV/AIDS, and basic science HIV/AIDS investigators wishing to conduct translational research). It will do so by leveraging existing infrastructure, resources and expertise, at modest incremental cost, to create broad synergies that can make a major impact on clinical and translational studies. Our experience as a D-CFAR has shown that providing that access to services alone is not necessarily sufficient to encourage new investigators to undertake translational HIV/AIDS projects. This has led us to develop a highly proactive, user-oriented, innovative approach, that includes consultation, advice and even identification and recruitment of study subjects (including data and/or specimens), and will support studies in hard-to-reach populations, by working with community organizations and existing UR infrastructure.
Aim 3 will provide training and education on human subjects research, including community-based studies, and will also conduct outreach to build trusting relationships with communities heavily impacted by HIV/AIDS.
Aim 4 will help to establish interdisciplinary collaborations, and Aim 5 will integrate Core activities with other institutional resources (including the UR CTSI).
|Zhang, Gang; Guo, Dongwei; Dash, Prasanta K et al. (2016) The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine 12:109-22|
|Piepenbrink, Michael S; Samuel, Memorie; Zheng, Bo et al. (2016) Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS One 11:e0158641|
|Fedor, Theresa M; Kohler, Hans-Peter; McMahon, James M (2016) Changing attitudes and beliefs towards a woman's right to protect against HIV risk in Malawi. Cult Health Sex 18:435-52|
|Nishimura, Christopher; Polesskaya, Oksana; Dewhurst, Stephen et al. (2016) Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation. J Vis Exp :e53582|
|Makita-Chingombe, Faithful; Kutscher, Hilliard L; DiTursi, Sara L et al. (2016) Poly(lactic-co-glycolic) Acid-Chitosan Dual Loaded Nanoparticles for Antiretroviral Nanoformulations. J Drug Deliv 2016:3810175|
|Blanchard, Catlyn; Brooks, Lauren; Ebsworth-Mojica, Katherine et al. (2016) Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment. mSphere 1:|
|Liu, Bilan; Qiu, Xing; Zhu, Tong et al. (2016) Spatial regression analysis of serial DTI for subject-specific longitudinal changes of neurodegenerative disease. Neuroimage Clin 11:291-301|
|Yang, Hongmei; Baker, Steven F; GonzÃ¡lez, Mario E et al. (2016) An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein. J Biopharm Stat 26:409-20|
|Blanchard, Catlyn; Brooks, Lauren; Beckley, Andrew et al. (2016) Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments. Antimicrob Agents Chemother 60:862-72|
|Jones, Letitia D; Jackson, Joseph W; Maggirwar, Sanjay B (2016) Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction. PLoS One 11:e0151702|
Showing the most recent 10 out of 128 publications