Abstract

Onchocerciasis is a parasitic disease which causes a severe dermatitis characterized by eosinophils and eosinophil major basic protein (MBP). The current proposal will use a murine model for onchocercal dermatitis to test the hypothesis that eosinophils are recruited to the skin b the C-C chemokine, eotaxin. Proposed studies will examine the temporal relationship of eotaxin with recruitment of eosinophils into the skin, and will use eotaxin gene knockout mice to test the prediction that eotaxin is required for development of onchocercal dermatitis. Proposed studies will also identify the cellular source(s) of eotaxin in the skin f mice with onchocercal dermatitis and will focus on the role of keratinocytes. The knowledge obtained from these studies will enhance the understanding of the role of chemokines in recruitment of leucocytes to the skin in this and other forms of dermatitis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR039750-09
Application #
6235754
Study Section
Project Start
1997-03-01
Project End
1998-02-28
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Das, Lopa M; Binko, Amy M; Traylor, Zachary P et al. (2018) Defining the timing of 25(OH)D rescue following nitrogen mustard exposure. Cutan Ocul Toxicol 37:127-132
Griffith, Alexis D; Zaidi, Asifa K; Pietro, Ashley et al. (2018) A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice. Sci Rep 8:14451
Zaidi, Asifa K; Spaunhurst, Katrina; Sprockett, Daniel et al. (2018) Characterization of the facial microbiome in twins discordant for rosacea. Exp Dermatol 27:295-298
Bhaskaran, Natarajan; Liu, Zhihui; Saravanamuthu, Senthil S et al. (2018) Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity. Front Immunol 9:184
Mukherjee, Pranab K; Chandra, Jyotsna; Retuerto, Mauricio et al. (2018) Effect of alcohol-based hand rub on hand microbiome and hand skin health in hospitalized adult stem cell transplant patients: A pilot study. J Am Acad Dermatol 78:1218-1221.e5
Monin, Leticia; Gudjonsson, Johann E; Childs, Erin E et al. (2017) MCPIP1/Regnase-1 Restricts IL-17A- and IL-17C-Dependent Skin Inflammation. J Immunol 198:767-775
Tacastacas, Joselin D; Chan, Derek V; Carlson, Sean et al. (2017) Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial. JAMA Dermatol 153:413-420
Swindell, William R; Sarkar, Mrinal K; Liang, Yun et al. (2017) RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin. Sci Rep 7:18045
Mullin, Nathaniel K; Mallipeddi, Nikhil V; Hamburg-Shields, Emily et al. (2017) Wnt/?-catenin Signaling Pathway Regulates Specific lncRNAs That Impact Dermal Fibroblasts and Skin Fibrosis. Front Genet 8:183
Arbiser, Jack L; Nowak, Ron; Michaels, Kellie et al. (2017) Evidence for biochemical barrier restoration: Topical solenopsin analogs improve inflammation and acanthosis in the KC-Tie2 mouse model of psoriasis. Sci Rep 7:11198

Showing the most recent 10 out of 403 publications