The SDRC Cell Culture and Molecular Technology Core (CCMTC) has played an important role in facilitatingskin-based research activity at the Case School of Medicine throughout its fifteen year history. During thistime, the core has provided basic services and training, and also state-of-the-art services, facilities andexpertise. The CCMTC has now developed into a major hub of research activity on campus and has anactive role in introducing new investigators to work on dermatological disease. The core is heavily engagedin providing a wide range of cultured skin cells to investigators, and in providing training in cell culturemethodology and molecular biology technology. The three major missions of the CCMTC include thefollowing.
Specific Aim I A primary goal of the CCMTC is to provide state-of-the-art cell culture andmolecular technology services and expertise, and cost savings to the Skin Diseases Research Center(SDRC) membership at the Case Western Reserve University School of Medicine, and to the largercommunity of researchers affiliated with the Case School of Medicine. The CCMTC has been verysuccessful in supplying investigators with new technology. This remains a core goal of the CCMTC. Inresponse to the demands of a changing scientific environment, the core has historically added new state-ofthe-art technology as it becomes available. In addition to the substantial list of technology that is presentlyoffered, we will now provide access, expertise and training in advanced real-time fluorescent imaging forvisualization of intracellular protein-protein interaction (FRET, FRAP, etc.), chip array analysis, andproteomics.
Specific Aim 2 A major goal of the CCMTC, in conjunction with the other SDRC cores, is toprovide cell and molecular technology, and expertise, that facilitates and encourages the translation of basicscience projects to the bedside. A major goal of the SDRC is to serve as a conduit that benefitsdermatologic therapy by bringing new diagnoistics and treatments to the bedside with the goal of improvingpatient care.
Specific Aim 3 The third goal of the CCMTC is to promote career development with a goal ofretaining talented young Ph.D. and M.D. investigators in the dermatologic sciences. This is achieved byproviding training to new investigators and senior investigators in technologies that will facilitate investigationof dermatologic diseases and by providing a forum for discussion of dematologic science.
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