This is a renewal application for the YRDRCC that was initially funded in August 2007. We focused our original application on two goals ~ bringing and disseminating new core technologies to investigators at Yale studying the rheumatic and immunological diseases and the inflammatory pathways that mediate their pathogenesis, and expanding the number of investigators and research base in these areas through these cores and an enrichment program. These goals were ambitious, particularly the former, in that we planned to build essentially from scratch two technologically sophisticated, research cores in the genesis and cryopreservation of genetically modified mice, and in in vivo imaging, rather than building upon existing infrastructure at the institution. We believe we have succeeded in these goals, developing and burnishing two highly productive research cores in the YRDRCC, offering novel technologies to a broad group of investigators, many of whom are new to rheumatic disease focused research, and we have used these cores and our enrichment activities to enhance collaborations in rheumatic and immunological diseases and to bring additional resources to Yale. We have also laid the groundwork for the next phase of the YRDRCC, outlined in this application, in which we intend to bring additional research technologies to Yale investigators, while offering an enrichment program that seeks to expand the use, and fruits, of these technologies by the broader national and international rheumatic and immunological research disease community. We still intend to serve as the Yale home for research into these illnesses, yet are determined over the next five years to expand the YRDRCC beyond Yale. The overall Goal of this renewal of the YRDRCC is to continue to foster a research environment dedicated to advancing our knowledge of the etiology, pathogenesis, and treatment of autoimmune and rheumatic diseases and the inflammatory pathways that mediate their pathogenesis. Toward this end, the Aims of the YRDRCC are to: 1) stimulate multidisciplinary collaborative investigation of the pathogenesis of the rheumatic diseases;2) to organize resources, techniques, and procedures into high quality, cost-efficient facilities used by multiple investigators, and to disseminate this technology and its fruits inside and outside th Yale community;and 3) to provide a rich educational environment that will encourage new and established investigators to study the rheumatic and immunological diseases, while providing them and investigators outside Yale, knowledge of advanced technological tools to carry forward such research.

Public Health Relevance

Coordination and integration of research and educational activities are critical to strengthening and expanding the study of rheumatic and immunological diseases and the inflammatory pathways that promote their pathogenesis. This Core Center will foster the continued development of research into these illnesses at Yale, and to broaden its impact beyond the borders of the institution.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30AR053495-08
Application #
8725461
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Mancini, Marie
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Assis, David N; Takahashi, Hiroki; Leng, Lin et al. (2016) A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Dig Dis Sci 61:3506-3512
Kumamoto, Yosuke; Hirai, Toshiro; Wong, Patrick W et al. (2016) CD301b(+) dendritic cells suppress T follicular helper cells and antibody responses to protein antigens. Elife 5:
Ols, Michelle L; Cullen, Jaime L; Turqueti-Neves, Adriana et al. (2016) Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand. Immunity 45:1052-1065
Laidlaw, Brian J; Craft, Joseph E; Kaech, Susan M (2016) The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol 16:102-11
Rompolas, Panteleimon; Mesa, Kailin R; Kawaguchi, Kyogo et al. (2016) Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Science 352:1471-4
Weinstein, Jason S; Herman, Edward I; Lainez, Begoña et al. (2016) TFH cells progressively differentiate to regulate the germinal center response. Nat Immunol 17:1197-205
Chae, Wook-Jin; Ehrlich, Allison K; Chan, Pamela Y et al. (2016) The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation. Immunity 44:246-58
Marshall, Heather D; Ray, John P; Laidlaw, Brian J et al. (2015) The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. Elife 4:e04851
Ray, John P; Staron, Matthew M; Shyer, Justin A et al. (2015) The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity 43:690-702
Housley, William J; Fernandez, Salvador D; Vera, Kenneth et al. (2015) Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli. Sci Transl Med 7:291ra93

Showing the most recent 10 out of 68 publications