This is competing renewal of the SDRC """"""""Molecular Analysis, Modeling and Correction of Skin Diseases Core Center"""""""". This is a broad based program on the University of Colorado Anschutz Medical Campus (UCAMC) with 56 members including 22 within the Department of Dermatology. Its goal is the correction of human skin diseases by molecular techniques. The first 4 years of this Center have been highly successful: SDRC investigators in collaborative projects or in P&F projects have added $20,371,611 in new research funding to the Institutional Research Base;The P&F program itself has shown a ~35-fold return on investment during the first 4 years. Collaborations within the SDRC have resulted in 71 published papers that were greatly supported by the Research Cores. The enrichment program and the management of collaborations have created a powerful collaborative network of investigators in skin disease related research. During the next 5 year period, we will add Xiao-Xing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz. We will retain 5 Cores (Administrative Core, Molecular Genetic Analysis Core, Bioengineering Core, Morphology and Phenotyping Core, and a Flow Cytometry Core), but the services offered will be altered and enhanced based on the experience of the first 4 years of funding, and on the suggestions of the Advisory Committee. The Enrichment Program will be greatly expanded by creating: A Global Skin Diseases Research Consortium to promote international research collaborations and speed the application of new science to exciting translational research projects A Mentorship Program """"""""A New Technology Program to facilitate research within the UCAMC-SDRC and in the Global Consortium. Translational research using treatments developed by this SDRC will be greatly enhanced by addition of new members to the Clinical Investigations Team, and by the availability of a new GMP facility in close proximity to the SDRC member laboratories and clinical facilities on the AMC.
This proposal will address research areas highly relevant to NIAMS priorities: biology of skin stem cells, regenerative medicine, developmental biology of the skin and appendages, melanocyte biology, keratinocyte differentiation, immune and inflammatory skin diseases, adaptive and innate immunity, identification of the genetic basis of skin disease and development of animal models to study those diseases.
|Ishitsuka, Yosuke; Huebner, Aaron J; Rice, Robert H et al. (2016) Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate forÂ the Loss of Loricrin. J Invest Dermatol 136:1656-63|
|Liu, Ying; Snedecor, Elizabeth R; Zhang, Xu et al. (2016) Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75. J Invest Dermatol 136:45-51|
|Reynolds, Susan D; Rios, Cydney; Wesolowska-Andersen, Agata et al. (2016) Airway Progenitor Clone Formation Is Enhanced by Y-27632-Dependent Changes in the Transcriptome. Am J Respir Cell Mol Biol 55:323-36|
|Mukherjee, Nabanita; Lu, Yan; Almeida, Adam et al. (2016) Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells. Oncotarget :|
|Tilley, Cynthia; Deep, Gagan; Agarwal, Chapla et al. (2016) Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation. Mol Carcinog 55:3-14|
|Zhang, Lei; Ferreyros, Michael; Feng, Weiguo et al. (2016) Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One 11:e0161465|
|Kohler, Stephanie L; Pham, Michael N; Folkvord, Joy M et al. (2016) Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication. J Immunol 196:2711-22|
|Jin, Ying; Andersen, Genevieve; Yorgov, Daniel et al. (2016) Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants. Nat Genet 48:1418-1424|
|Du, L; Chen, X; Cao, Y et al. (2016) Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFÎ² signaling. Oncogene 35:4641-52|
|Morton, J J; Bird, G; Keysar, S B et al. (2016) XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. Oncogene 35:290-300|
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