This is competing renewal of the SDRC "Molecular Analysis, Modeling and Correction of Skin Diseases Core Center". This is a broad based program on the University of Colorado Anschutz Medical Campus (UCAMC) with 56 members including 22 within the Department of Dermatology. Its goal is the correction of human skin diseases by molecular techniques. The first 4 years of this Center have been highly successful: SDRC investigators in collaborative projects or in P&F projects have added $20,371,611 in new research funding to the Institutional Research Base;The P&F program itself has shown a ~35-fold return on investment during the first 4 years. Collaborations within the SDRC have resulted in 71 published papers that were greatly supported by the Research Cores. The enrichment program and the management of collaborations have created a powerful collaborative network of investigators in skin disease related research. During the next 5 year period, we will add Xiao-Xing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz. We will retain 5 Cores (Administrative Core, Molecular Genetic Analysis Core, Bioengineering Core, Morphology and Phenotyping Core, and a Flow Cytometry Core), but the services offered will be altered and enhanced based on the experience of the first 4 years of funding, and on the suggestions of the Advisory Committee. The Enrichment Program will be greatly expanded by creating: A Global Skin Diseases Research Consortium to promote international research collaborations and speed the application of new science to exciting translational research projects A Mentorship Program "A New Technology Program to facilitate research within the UCAMC-SDRC and in the Global Consortium. Translational research using treatments developed by this SDRC will be greatly enhanced by addition of new members to the Clinical Investigations Team, and by the availability of a new GMP facility in close proximity to the SDRC member laboratories and clinical facilities on the AMC.
This proposal will address research areas highly relevant to NIAMS priorities: biology of skin stem cells, regenerative medicine, developmental biology of the skin and appendages, melanocyte biology, keratinocyte differentiation, immune and inflammatory skin diseases, adaptive and innate immunity, identification of the genetic basis of skin disease and development of animal models to study those diseases.
|Mukherjee, Nabanita; Reuland, Steven N; Lu, Yan et al. (2015) Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells including melanoma initiating cells. J Invest Dermatol 135:842-50|
|O'Shea, Charlene; Fitzpatrick, James E; Koch, Peter J (2014) Desmosomal defects in acantholytic squamous cell carcinomas. J Cutan Pathol 41:873-9|
|Luo, Yuchun; Cai, Xiangna; Liu, Sucai et al. (2014) Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci U S A 111:15178-83|
|Barón, Anna E; Asdigian, Nancy L; Gonzalez, Victoria et al. (2014) Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. Cancer Epidemiol Biomarkers Prev 23:2829-39|
|Koch, Peter J; Dinella, Jason; Fete, Mary et al. (2014) Modeling AEC-New approaches to study rare genetic disorders. Am J Med Genet A 164A:2443-54|
|Kogut, Igor; Roop, Dennis R; Bilousova, Ganna (2014) Differentiation of human induced pluripotent stem cells into a keratinocyte lineage. Methods Mol Biol 1195:1-12|
|Bilousova, Ganna; Roop, Dennis R (2014) Induced pluripotent stem cells in dermatology: potentials, advances, and limitations. Cold Spring Harb Perspect Med 4:a015164|
|Riemondy, Kent; Hoefert, Jaimee E; Yi, Rui (2014) Not miR-ly micromanagers: the functions and regulatory networks of microRNAs in mammalian skin. Wiley Interdiscip Rev RNA 5:849-65|
|Deng, Hui; Li, Fulun; Li, Hong et al. (2014) CtBP1 overexpression in keratinocytes perturbs skin homeostasis. J Invest Dermatol 134:1323-31|
|Dinella, Jason; Koster, Maranke I; Koch, Peter J (2014) Use of induced pluripotent stem cells in dermatological research. J Invest Dermatol 134:e23|
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