The Pathology Core will be widely used by cutaneous investigators to aid in understanding function. This Core will provide service, instruction and interpretation. Since light microscopy and specifically routine histology and immunohistochemistry were indicated to be of the greatest general use to the SDRC members, service will be in the form of tissue processing, sectioning and staining to elucidate the morphology of specific epithelia. Investigators will be able to detect expression of genes at the message and protein levels through the use of in situ hybridization and immunohistochemical techniques, respectively. Another unique feature of the Pathology Core highly requested by SDRC users is access to a library of epithelia from various laboratory species, and the Core will include a tissue repository. Service will be in the form of expertise and instruction in more highly specialized morphological services such as laser capture microdissection, novel antibody evaluation and computer-assisted image analysis. Interpretation will help investigators evaluate whether phenotypic changes seen in epithelia from their engineered mice are different from those of wild type mice. This feature of the Core draws on the expertise that the Director and co-Directors have in investigating numerous stratified squamous epithelia and their appendages. We anticipate, based on our experience that the Pathology core will provide services, training and interpretative abilities that exceed the capabilities of the individual investigators and thus will result in the strengthening and the development of new collaborative ventures in epithelial biology.

Public Health Relevance

Morphological characterization of tissues has been a one of the primary means of understanding function. The need for this these types of analyses have become even more important with the advancement in production of genetically engineered mice, which require detailed morphological descriptions of their unique phenotypes. The Pathology Core will provide SDRC members with a variety of morphological techniques and interpretative expertise to facilitate their studies. Thus collaborations among epithelial biologists at Northwestern University will be enhanced and expanded.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-KM-D)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
United States
Zip Code
Sarkar, Mrinal K; Kaplan, Nihal; Tsoi, Lam C et al. (2017) Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation. J Invest Dermatol 137:1474-1483
Bagchi, Sreya; He, Ying; Zhang, Hong et al. (2017) CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice. J Clin Invest 127:2339-2352
Dam, Duncan Hieu M; Wang, Xiao-Qi; Sheu, Sarah et al. (2017) Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility. J Invest Dermatol 137:440-448
Najor, Nicole Ann; Fitz, Gillian Nicole; Koetsier, Jennifer Leigh et al. (2017) Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex. Elife 6:
Park, Jong Kook; Peng, Han; Yang, Wending et al. (2017) miR-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J 31:256-265
Hamanaka, Robert B; Mutlu, Gökhan M (2017) PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes. J Invest Dermatol 137:1267-1276
Wood, Megan N; Ishiyama, Noboru; Singaram, Indira et al. (2017) ?-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion. J Cell Biol 216:3767-3783
Ratsimandresy, Rojo A; Chu, Lan H; Khare, Sonal et al. (2017) The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation. Nat Commun 8:15556
Perez White, Bethany E; Ventrella, Rosa; Kaplan, Nihal et al. (2017) EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions. J Cell Sci 130:111-118
Park, Jong Kook; Peng, Han; Katsnelson, Julia et al. (2016) MicroRNAs-103/107 coordinately regulate macropinocytosis and autophagy. J Cell Biol 215:667-685

Showing the most recent 10 out of 92 publications