Measures of structure and strength are essential when assessing functional outcomes in animal models related to musculoskeletal biology and medicine. In 2008, evaluation of these outcomes at Washington University (WU) was limited to a handful of investigators because we lacked a formal support structure. Evaluating these outcomes requires specialized equipment and expertise, which is impractical and inefficient to recreate in multiple labs. In response to this unmet need, we established the Musculoskeletal Structure and Strength Core. This multifaceted resource supports our 75-member Research Base in understanding and implementing techniques to evaluate structure and mechanical properties of musculoskeletal tissues (e.g., bone, tendon, muscle) derived from animal models. Since 2009, we have provided billable services to 59 investigators, who have reported structure or strength data in 68 manuscripts to date. We have presented seminars and developed online resources to advance understanding and promote best practices. We have invested in new approaches to enhance our capabilities. Finally, we moved and consolidated our major resources into a single floor of the new WU Musculoskeletal Research Center. To sustain and extend these accomplishments, we propose five objectives: 1) support cost-effective utilization of existing resources for densitometry, imaging, and mechanical testing;2) maintain expert oversight and quality control;3) provide training and enrichment opportunities (in concert with the T32 Washington University Metabolic Skeletal Disorders Training Program);4) enhance Core capabilities through development of new techniques;and 5) foster new interactions and enhance existing interactions between members of the Research Base of the Core Center for Musculoskeletal Biology and Medicine (CCMBM). In summary, Core B will provide critical support to members of the Research Base to enable cost-effective utilization of methods to quantify morphology and mechanical properties from musculoskeletal tissues. Through our efforts we will enhance research productivity and provide access to state-of-the-art and emerging techniques.

Public Health Relevance

Musculoskeletal disorders such as osteoarthritis, osteoporosis and muscular dystropy are a main cause of pain and suffering leading to diminished quality and lost time from work. Our research uses animal models to understand the biological factors underlying musculoskeletal disorders. We use imaging and mechanical testing techniques to assess the structure and strength of bone, tendon and muscle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
2P30AR057235-06
Application #
8708693
Study Section
Special Emphasis Panel ()
Project Start
Project End
Budget Start
2014-04-05
Budget End
2015-03-31
Support Year
6
Fiscal Year
2014
Total Cost
$158,718
Indirect Cost
$54,555
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Diez-Perez, A; Bouxsein, M L; Eriksen, E F et al. (2016) Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation. Bone Rep 5:181-185
Gelberman, Richard H; Shen, Hua; Kormpakis, Ioannis et al. (2016) Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study. J Orthop Res 34:630-40
Blanton, Laura V; Charbonneau, Mark R; Salih, Tarek et al. (2016) Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science 351:
Singh, Sudhir; Manson, Scott R; Lee, Heedoo et al. (2016) Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis. PLoS One 11:e0158908
Agapova, Olga A; Fang, Yifu; Sugatani, Toshifumi et al. (2016) Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease. Kidney Int 89:1231-43
Kim, Yeawon; Lee, Heedoo; Manson, Scott R et al. (2016) Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Urine Biomarker for Endoplasmic Reticulum Stress-Related Kidney Diseases. J Am Soc Nephrol 27:2974-2982
Black, James C; Ricci, William M; Gardner, Michael J et al. (2016) Novel Augmentation Technique for Patellar Tendon Repair Improves Strength and Decreases Gap Formation: A Cadaveric Study. Clin Orthop Relat Res 474:2611-2618
Kormpakis, Ioannis; Linderman, Stephen W; Thomopoulos, Stavros et al. (2016) Enhanced Zone II Flexor Tendon Repair through a New Half Hitch Loop Suture Configuration. PLoS One 11:e0153822
Yan, Huimin; Duan, Xin; Pan, Hua et al. (2016) Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury. Proc Natl Acad Sci U S A 113:E6199-E6208
Shashkova, Elena V; Trivedi, Jahnavi; Cline-Smith, Anna B et al. (2016) Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption. J Immunol 197:726-35

Showing the most recent 10 out of 251 publications