The overall goal of the Center for Skeletal Research is to foster Interdisciplinary and collaborative work that leads to a deeper understanding of skeletal biology, in a way that can lead to new ways of diagnosing and treating skeletal diseases. The Center will build upon and expand a community of bone scientists in the Endocrine Unit and other Units at the Massachusetts General Hospital, the Harvard School of Dental Medicine, and other Harvard-associated departments and institutions. This group has already defined itself through a network of collaborations and a monthly seminar series sponsored jointly by the MGH Endocrine Unit and the Harvard School of Dental Medicine, and includes bone scientists from multiple Harvard institutions. These scientists are diverse, including clinical investigators and laboratory investigators using a broad array of approaches from multiple disciplines. The mechanisms that the Center will use to accomplish its goal include Core Facilities, a Pilot and Feasibility Grant Program, and a seminar series. The Cores will include a Skeletal Phenotyping Core and a Bone Cells and Signaling Core. These Cores will emphasize the development of new techniques that can drive the science of Center investigators, as well as the provision of expert and efficient service. The goal of the Pilot and Feasibility Grant Program will be to allow young investigators to develop sufficient data to obtain their own grants; in that context, a vigorous mentoring program will complement the funding. The seminar series will foster collaboration and communication among Center scientists. Young investigators will present current data in some sessions, while others will bring in distinguished bone scientists from outside of Boston to enrich the environment. This series will also include presentations by Core Directors that explain the techniques used in the Cores and will provide a forum for feedback by Center investigators that will include suggestions for novel Core services. An Administrative Core will assure effective functioning of these activities through regular meetings of Core Directors that, four times a year, will also involve meeting with an Advisory Committee made up of senior investigators within the Center, as well as investigators from elsewhere with relevant experience leading similar programs. The Center will be committed to sharing its innovations with the broader community of bone scientists across the country.

Public Health Relevance

This Center for Skeletal Research will further the discovery of the causes and therapies for skeletal diseases through the provision of core facilities and other programs designed to make the wok of a broad array of investigators more efficient, interdisciplinary, innovative and interactive. By making this research more effective, advances in understanding and therapy of osteoporosis and other bone disease will occur more quickly.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
5P30AR066261-04
Application #
9285601
Study Section
Special Emphasis Panel (ZAR1-XZ (M1))
Program Officer
Chen, Faye H
Project Start
2014-06-01
Project End
2019-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
4
Fiscal Year
2017
Total Cost
$696,000
Indirect Cost
$296,000
Name
Massachusetts General Hospital
Department
Type
Independent Hospitals
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Saini, Vaibhav; Zhao, Hengguang; Petit, Elizabeth T et al. (2017) Absence of vitamin D receptor (VDR)-mediated PPAR? suppression causes alopecia in VDR-null mice. FASEB J 31:1059-1066
Fulzele, Keertik; Lai, Forest; Dedic, Christopher et al. (2017) Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots. J Bone Miner Res 32:373-384
Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M et al. (2017) Knockin mouse with mutant G?11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. JCI Insight 2:e91079
Papaioannou, Garyfallia; Petit, Elizabeth T; Liu, Eva S et al. (2017) Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem 292:3164-3171
Kitano, Kentaro; Schwartz, Dana M; Zhou, Haiyang et al. (2017) Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nat Commun 8:765
Bornstein, Sheila; Moschetta, Michele; Kawano, Yawara et al. (2017) Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology 158:3369-3385
Engblom, Camilla; Pfirschke, Christina; Zilionis, Rapolas et al. (2017) Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science 358:
Li, Yuwen; Caballero, Daniel; Ponsetto, Julian et al. (2017) Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One 12:e0176232
He, Qing; Bouley, Richard; Liu, Zun et al. (2017) Large G protein ?-subunit XL?s limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proc Natl Acad Sci U S A 114:E9559-E9568
Guo, Jun; Khatri, Ashok; Maeda, Akira et al. (2017) Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. J Bone Miner Res 32:86-98

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