The goal of the Musculoskeletal Imaging and Image Processing Research (MQIR) Core is to provide customized image acquisition, reconstruction and quantitative analysis for pre-clinical (tissue samples and animal models), and human quantitative imaging in musculoskeletal diseases.The MQIR Core has the following aims as part of its contribution to the overall mission of the CCMBM.
Specific Aim I : To provide quantitative magnetic resonance imaging sequences, computed tomography (CT) and positron emission tomography (PET) methods for pre-clinical and human musculoskeletal tissues.
Specific Aim II : To develop novel image grading and quantitative analysis: To provide templates, training, and implement robust measures for clinical grading of radiographs, CT and MR images, software packages for post-processing, visualization and quantitative analysis of images.
Specific Aim III : To provide interpretation of imaging data and assess links to biochemical, histological, and biomechanical measures. Develop and maintain databases for proposed projects that record parameters that are extracted from single and serial imaging examinations and the relevant clinical or experimental endpoints.
Specific Aim I V: We will provide a web portal, examples of previous studies that have used imaging endpoints and detailed descriptions of clinical and research imaging services will be represented on the web portal. On-line requests from new users for research collaboration and service will be reviewed by the staff, and based on the studies, initial consultation with appropriate individuals will be set up. Post-processing and imaging informatics will be provided to assist researchers design studies and apply for their Pilot and Feasibility grants.
Specific Aim V : We will also perform proactive outreach to attract potential new users, participate in CCMBM seminar activities to provide imaging seminars and workshops to introduce new imaging, image processing, to the Core community.

Public Health Relevance

The Core will assist researchers o link non-invasive imaging to study diseases such as osteoarthritis, sports related injuries, osteoporosis and muscuo-skeletal degenration. It will enable us to understand the musculoskeletal system in health, aging, and degeneration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Center Core Grants (P30)
Project #
1P30AR066262-01
Application #
8708435
Study Section
Special Emphasis Panel (ZAR1-XZ (M1))
Project Start
2014-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$214,941
Indirect Cost
$89,170
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Joo, Adriane; Long, Roger; Cheng, Zhiqiang et al. (2016) Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone 88:170-9
Zhang, M; Wang, H; Zhang, J et al. (2016) Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Osteoarthritis Cartilage 24:921-31
Kim, Wonnam; Takyar, Farzin M; Swan, Karena et al. (2016) Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res 76:5348-60
Almubarak, Sarah; Nethercott, Hubert; Freeberg, Marie et al. (2016) Tissue engineering strategies for promoting vascularized bone regeneration. Bone 83:197-209
Jáuregui, Emmanuel J; Akil, Omar; Acevedo, Claire et al. (2016) Parallel mechanisms suppress cochlear bone remodeling to protect hearing. Bone 89:7-15
Zhang, Alan L; Sing, David C; Dang, Debbie Y et al. (2016) Overlapping Surgery in the Ambulatory Orthopaedic Setting. J Bone Joint Surg Am 98:1859-1867
Santa Maria, Christian; Cheng, Zhiqiang; Li, Alfred et al. (2016) Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol 49:11-23
Degmetich, Sean; Bailey, Jeannie F; Liebenberg, Ellen et al. (2016) Neural innervation patterns in the sacral vertebral body. Eur Spine J 25:1932-8
Yang, T; Zhang, J; Cao, Y et al. (2015) Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling. J Dent Res 94:803-12
Wang, Tao; Wang, Yongmei; Menendez, Alicia et al. (2015) Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res 30:1572-84

Showing the most recent 10 out of 14 publications