Fox Chase Cancer Center (FCCC) established biospecimen banking activities in 1987 to coordinate the ethical collection, storage, annotation, and distribution of tissue and peripheral blood samples to support translational research. This centralized, Center-wide activity is under the supervision of Boyd (Leader, Women's Cancer (WC) Program) within the Department of Pathology, and is overseen by an interprogrammatic Facility Advisory Committee (FAC). The Biosample Repository Facility (BRF) is a College of American Pathologists (CAP)-accrediled and CLIA-certified Facility that has two major functions: 1) identify participants, obtain informed consent, collect tissue, blood, and/or urine samples from selected populations, and obtain information on personal and family histories of cancer, clinical intervention, and lifestyle factors for use in research;and 2) process and store human biospecimens obtained through investigator-initiated studies. Working in collaboration with pathologists, medical oncologists, surgeons and other hospital personnel, specially trained BRF staff obtain subject informed consent, collect samples, and assemble comprehensive clinical, pathological, and personal/demographic information about each donor and the corresponding samples. As part of this banking process, the BRF staff provides: 1) outstanding diagnostic pathology support;2) a comprehensive informed consent process for the appropriate use of tissue, blood, and other biospecimens for research;3) a specialized biospecimen bank devoted to the collection and distribution of specimens to support research;and 4) extensive supporting data from the clinical record and self-reported health history of each participant. All specimens are linked to comprehensive clinical databases supported by the Population Studies Facility (PSF). The BRF currently houses over 11,000 fresh-frozen tissue samples, over 29,000 blood samples, and has access to >100,000 surgical pathology cases. The BRF has served 26 FCCC investigators (24 peer-reviewed, funded in CY 2009) across all five CCSG Programs. Ninety-six percent (96%) of the BRF's CY, 2009 use is by peer-reviewed, funded investigators. (See usage table Section V).

Public Health Relevance

Translational research requires ready access to a robust and thoroughly annotated collection of human biosamples, obtained through a process of appropriate informed consent. Thus, a centralized Facility such as the BRF is essential to the research mission of a comprehensive cancer center such as the FCCC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
7P30CA006927-50
Application #
8475345
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
50
Fiscal Year
2013
Total Cost
$88,679
Indirect Cost
Name
Research Institute of Fox Chase Cancer Center
Department
Type
DUNS #
064367329
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Heckman, Carolyn J; Handorf, Elizabeth A; Darlow, Susan D et al. (2016) An Online Skin Cancer Risk-Reduction Intervention for Young Adults: Mechanisms of Effects. Health Psychol :
Boland, Patrick M; Meyer, Joshua E; Berger, Adam C et al. (2016) Induction Therapy for Locally Advanced, Resectable Esophagogastric Cancer: A Phase I Trial of Vandetanib (ZD6474), Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiotherapy Followed by Resection. Am J Clin Oncol :
Hayakawa, K; Formica, A M; Colombo, M J et al. (2016) Loss of a chromosomal region with synteny to human 13q14 occurs in mouse chronic lymphocytic leukemia that originates from early-generated B-1 B cells. Leukemia 30:1510-9
Meropol, Neal J; Wong, Yu-Ning; Albrecht, Terrance et al. (2016) Randomized Trial of a Web-Based Intervention to Address Barriers to Clinical Trials. J Clin Oncol 34:469-78
Duong-Ly, Krisna C; Devarajan, Karthik; Liang, Shuguang et al. (2016) Kinase Inhibitor Profiling Reveals Unexpected Opportunities to Inhibit Disease-Associated Mutant Kinases. Cell Rep 14:772-81
Tan, Yinfei; Xin, Xiaoban; Coffey, Francis J et al. (2016) Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. J Cell Physiol 231:1142-50
Geynisman, Daniel M; Handorf, Elizabeth; Wong, Yu-Ning et al. (2016) Advanced small cell carcinoma of the bladder: clinical characteristics, treatment patterns and outcomes in 960 patients and comparison with urothelial carcinoma. Cancer Med 5:192-9
Meeker, Caitlin R; Geynisman, Daniel M; Egleston, Brian L et al. (2016) Relationships Among Financial Distress, Emotional Distress, and Overall Distress in Insured Patients With Cancer. J Oncol Pract 12:e755-64
Borczuk, Alain C; Pei, Jianming; Taub, Robert N et al. (2016) Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration. Cancer Biol Ther 17:328-35
Kurimchak, Alison M; Shelton, Claude; Duncan, Kelly E et al. (2016) Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer. Cell Rep 16:1273-86

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