Many Fox Chase Cancer Center (FCCC) studies, including those in cancer control and prevention, translational research, human genetics, behavioral medicine and some animal trials employ a variety of designs that are substantially more complex than typical cancer clinical trials. These investigations require development of study-specific information systems for project management, and the collection, validation, storage, and retrieval of data. The Population Studies Facility (PSF) facilitates research conducted by FCCC peer-reviewed, funded investigators by providing access to a team of information systems professionals with experience in state-of-the-art software engineering applied to cancer research. The PSF functions include development of;databases for the storage and manipulation of large quantities of questionnaire, clinical, molecular and specimen data;electronic data entry and retrieval systems;report generation software;consistency and quality control systems;and systems that provide integration and controlled exchange of data from diverse sources. For example, the system developed by the PSF for the "Breast Cancer Family Registry" study provides for the entry, coordination and retrieval of longitudinal information, specimen inventory, genetic testing, and complex pedigree data. The PSF also provides systems that facilitate the peer-reviewed, funded investigator support activities of many CCSG-supported cores. The PSF has developed information systems that maintain data on over 180,000 subjects. Of these, more than 60,000 were enrolled in FCCC studies within the US;the remainder participated in several international cohort studies. The PSF provided services to 54 peer-reviewed, funded investigators in all five Programs and 129 projects over the last five years. These represent 35% and 6 1% increases in the number of supported investigators and projects, respectively, over the previous funding cycle. Improved application development efficiency provided by the PSF's creation of the Population Research Application Generation Environment (PRESAGE) toolset and the use of open source solutions has allowed the PSF to accommodate the increase in demand for informatics services with only a 9% increase in staffing. The PSF made contributions to 100 manuscripts and PSF personnel have appeared as co-authors on 47 publications over the current funding period. It has a user charge back system that, combined with other direct grant funding, recoups 74% of its operating cost. In 2009, 66.2% of its use was directly for peer-reviewed, funded investigators. This Facility was rated "Outstanding" during the last review.
The Population Studies Facility (PSF) provides state of the art software engineering applied to cancer research which include: database storage, manipulation of large quantities of questionnaires, clinical and other data entry and retrieval systems. The PSF is critical in maintaining data on over 180,000 subjects.
|Austin, Steven R; Wong, Yu-Ning; Uzzo, Robert G et al. (2015) Why Summary Comorbidity Measures Such As the Charlson Comorbidity Index and Elixhauser Score Work. Med Care 53:e65-72|
|Bassi, Daniel E; Cenna, Jonathan; Zhang, Jirong et al. (2015) Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6). Mol Carcinog 54:1122-31|
|Sherman, Kerry A; Miller, Suzanne M; Roussi, Pagona et al. (2015) Factors predicting adherence to risk management behaviors of women at increased risk for developing lymphedema. Support Care Cancer 23:61-9|
|Eytan, Esther; Wang, Kexi; Miniowitz-Shemtov, Shirly et al. (2014) Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet). Proc Natl Acad Sci U S A 111:12019-24|
|Johnson, Matthew E; Handorf, Elizabeth A; Martin, Jeffrey M et al. (2014) Postmastectomy radiation therapy for T3N0: a SEER analysis. Cancer 120:3569-74|
|Gabitova, Linara; Gorin, Andrey; Astsaturov, Igor (2014) Molecular pathways: sterols and receptor signaling in cancer. Clin Cancer Res 20:28-34|
|Silverman, Diana; Ruth, Karen; Sigurdson, Elin R et al. (2014) Skin involvement and breast cancer: are T4b lesions of all sizes created equal? J Am Coll Surg 219:534-44|
|Gupta, Sapna; Melnyk, Stepan B; Kruger, Warren D (2014) Cystathionine *-synthase-deficient mice thrive on a low-methionine diet. FASEB J 28:781-90|
|Simhan, Jay; Smaldone, Marc C; Egleston, Brian L et al. (2014) Nephron-sparing management vs radical nephroureterectomy for low- or moderate-grade, low-stage upper tract urothelial carcinoma. BJU Int 114:216-20|
|Gowrishankar, Banumathy; Ibragimova, Ilsiya; Zhou, Yan et al. (2014) MicroRNA expression signatures of stage, grade, and progression in clear cell RCC. Cancer Biol Ther 15:329-41|
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