The Animal Imaging Core provides a wide array of non-invasive, high resolution quantitative imaging-based capabilities for metabolic and genetic characterization of tumors and their microenvironment. Among the critical scientific applications of small-animal imaging by MSKCC investigators are: phenotypic screening of tumor incidence, progression and therapy-induced regression in xenograft models and transgenic/knock-out models;assessment of trafficking of cancer cells, stem cells, and immune effector cells in vivo;evaluation of trans-gene expression, development, testing, and validation of targeted therapies (i.e. pharmacodynamics); and detection and localization of tumor hypoxia and re-oxygenation. These capabilities are broadly applicable to the fundamental mission of the Center in areas such as molecular imaging, assessment of therapeutic response, and drug development. The services provided by the Animal Imaging Core has supported the research of 65 investigators in the past year. During the past grant period the work of the Core has contributed to 370 publications of researchers from 9 research programs. As part of a major expansion and modernization of MSKCC's infrastructure, the Imaging Core has been consolidated and re-located to the Zuckerman Research Center's vivarium. This area provides enhanced biosecurity and functionality and houses the R4 and Focus 120 microPET, ivis 100 opfical imaging system, microCATII, microCT, NanoSPECT/CT Plus, SPECT-CT, Maestro, FMT 2500 near-Infrared fluorescence tomography system, and Vevo 2100 ultrasound system. The existing Ivis 100 optical imaging system remains at the Rockefeller Research Laboratory, supporting investigators In that building. A new high precision microirradiator, X-RAD, for rodent tumors and other structures was installed in 2012. The Core's 4.7T and 7.0T Brucker USR systems have also been moved to the Vivarium. The Core has provided critical support for the development and characterization of mouse models for human cancer. For example, models for glioma driven by PDGF-B signaling and anaplastic thyroid tumors driven by inducible mutant BRAF have been extensively characterized and examined for therapeutic responses using the imaging resources of the Core.
The Animal Imaging Core Provides non-invasive, high resolution quantitative imaging-based capabilities for metabolic and genetic characterization of tumors and their microenvironment. These capabilities which are broadly applicable to the fundamental mission of the Center in such diverse and important space areas as molecular imaging, assessment of treatment response, and drug development.
|Pak, Linda M; Gonen, Mithat; Seier, Kenneth et al. (2018) Can physician gestalt predict survival in patients with resectable pancreatic adenocarcinoma? Abdom Radiol (NY) 43:2113-2118|
|Thomas, Rozario; Marks, Daniel Henry; Chin, Yvette et al. (2018) Whole chromosome loss and associated breakage-fusion-bridge cycles transform mouse tetraploid cells. EMBO J 37:201-218|
|Shoag, Jonathan; Liu, Deli; Blattner, Mirjam et al. (2018) SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG. J Clin Invest 128:381-386|
|Abreu, Carla M; Prakash, Rohit; Romanienko, Peter J et al. (2018) Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination. Nat Commun 9:3961|
|Katsoulakis, Evangelia; Leeman, Jonathan E; Lok, Benjamin H et al. (2018) Long-term outcomes in oral cavity squamous cell carcinoma with adjuvant and salvage radiotherapy after surgery. Laryngoscope 128:2539-2545|
|Huicochea Castellanos, Sandra; Corrias, Giuseppe; Ulaner, Gary A et al. (2018) Detection of recurrent pancreatic cancer: value of second-opinion interpretations of cross-sectional images by subspecialized radiologists. Abdom Radiol (NY) :|
|Hoseini, Sayed Shahabuddin; Guo, Hongfen; Wu, Zhihao et al. (2018) A potent tetravalent T-cell-engaging bispecific antibody against CD33 in acute myeloid leukemia. Blood Adv 2:1250-1258|
|Attiyeh, Marc A; Fernández-Del Castillo, Carlos; Al Efishat, Mohammad et al. (2018) Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium. Ann Surg 267:157-163|
|Tollinche, Luis; Tan, KaySee; Han, Austin et al. (2018) Analyzing Volatile Anesthetic Consumption by Auditing Fresh Gas Flow: An Observational Study at an Academic Hospital. Int J Anesth Anesth 5:|
|Tadros, Audree B; Wen, Hannah Y; Morrow, Monica (2018) Breast Cancers of Special Histologic Subtypes Are Biologically Diverse. Ann Surg Oncol 25:3158-3164|
Showing the most recent 10 out of 8799 publications