The Animal Imaging Core provides a wide array of non-invasive, high resolution quantitative imaging-based capabilities for metabolic and genetic characterization of tumors and their microenvironment. Among the critical scientific applications of small-animal imaging by MSKCC investigators are: phenotypic screening of tumor incidence, progression and therapy-induced regression in xenograft models and transgenic/knock-out models;assessment of trafficking of cancer cells, stem cells, and immune effector cells in vivo;evaluation of trans-gene expression, development, testing, and validation of targeted therapies (i.e. pharmacodynamics); and detection and localization of tumor hypoxia and re-oxygenation. These capabilities are broadly applicable to the fundamental mission of the Center in areas such as molecular imaging, assessment of therapeutic response, and drug development. The services provided by the Animal Imaging Core has supported the research of 65 investigators in the past year. During the past grant period the work of the Core has contributed to 370 publications of researchers from 9 research programs. As part of a major expansion and modernization of MSKCC's infrastructure, the Imaging Core has been consolidated and re-located to the Zuckerman Research Center's vivarium. This area provides enhanced biosecurity and functionality and houses the R4 and Focus 120 microPET, ivis 100 opfical imaging system, microCATII, microCT, NanoSPECT/CT Plus, SPECT-CT, Maestro, FMT 2500 near-Infrared fluorescence tomography system, and Vevo 2100 ultrasound system. The existing Ivis 100 optical imaging system remains at the Rockefeller Research Laboratory, supporting investigators In that building. A new high precision microirradiator, X-RAD, for rodent tumors and other structures was installed in 2012. The Core's 4.7T and 7.0T Brucker USR systems have also been moved to the Vivarium. The Core has provided critical support for the development and characterization of mouse models for human cancer. For example, models for glioma driven by PDGF-B signaling and anaplastic thyroid tumors driven by inducible mutant BRAF have been extensively characterized and examined for therapeutic responses using the imaging resources of the Core.
The Animal Imaging Core Provides non-invasive, high resolution quantitative imaging-based capabilities for metabolic and genetic characterization of tumors and their microenvironment. These capabilities which are broadly applicable to the fundamental mission of the Center in such diverse and important space areas as molecular imaging, assessment of treatment response, and drug development.
|Steuer, Conor E; Behera, Madhusmita; Berry, Lynne et al. (2016) Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium. Cancer 122:766-72|
|Dominguez-Rosado, Ismael; Moutinho Jr, Vitor; DeMatteo, Ronald P et al. (2016) Outcomes of the Memorial Sloan Kettering Cancer Center International General Surgical Oncology Fellowship. J Am Coll Surg 222:961-6|
|Iasonos, Alexia; O'Quigley, John (2016) Integrating the escalation and dose expansion studies into a unified Phase I clinical trial. Contemp Clin Trials 50:124-34|
|Brown, Anna M; Nagala, Sidhartha; McLean, Mary A et al. (2016) Multi-institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion-weighted MRI. Magn Reson Med 75:1708-16|
|Akkari, Leila; Gocheva, Vasilena; Quick, Marsha L et al. (2016) Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev 30:220-32|
|Theilen, Till M; Chou, Alexander J; Klimstra, David S et al. (2016) Esophageal Adenocarcinoma and Squamous Cell Carcinoma in Children and Adolescents: Report of 3 Cases and Comprehensive Literature Review. J Pediatr Surg Case Rep 5:23-29|
|Robinson, June K; Halpern, Allan C (2016) Cost-effective Melanoma Screening. JAMA Dermatol 152:19-21|
|Calzavara-Pinton, Pier Giacomo; Rossi, Maria Teresa; Zanca, Arianna et al. (2016) Oral Polypodium leucomotos increases the anti-inflammatory and melanogenic responses of the skin to different modalities of sun exposures: a pilot study. Photodermatol Photoimmunol Photomed 32:22-7|
|Ripley, R Taylor; Suzuki, Kei; Tan, Kay See et al. (2016) Postinduction positron emission tomography assessment of N2 nodes is not associated with ypN2 disease or overall survival in stage IIIA non-small cell lung cancer. J Thorac Cardiovasc Surg 151:969-77, 979.e1-3|
|Chapuis, Aude G; Roberts, Ilana M; Thompson, John A et al. (2016) T-Cell Therapy Using Interleukin-21-Primed Cytotoxic T-Cell Lymphocytes Combined With Cytotoxic T-Cell Lymphocyte Antigen-4 Blockade Results in Long-Term Cell Persistence and Durable Tumor Regression. J Clin Oncol :|
Showing the most recent 10 out of 4768 publications