The Bioinformatics Facility provides Cancer Center investigators with database management, software applications support, and expertise in statistical analyses and computational modeling of biomedical research data. In response to the growing informatics needs of funded Cancer Center researchers, the Bioinformatics Facility was established in 2001 with a combination of Cancer Center developmental funds and institutional support. The Cancer Center has made major investments to increase Bioinformatics facility space, instrumentation, and personnel over the past funding period. Under the direction of Dr. Ramana Davuluri, Director of Computational Biology, the Bioinformatics Facility has recently grown to consist of faculty, programmers, and statistical specialists from the Center for Systems and Computational Biology. Functions of the Facility reflect the research requirements of the three Cancer Center programs and are broadly divided into three areas: (i) data-management;(ii) statistical analyses and computational modeling; and (iii) advanced bioinformatics tools for integrative cancer biology. Specific services of the Bioinformatics Facility are to: 1) provide computational support for use of database software and bioinformatics tools;2) provide consulting support regarding statistical design and data analyses for high-throughput experiments;3) provide shared archives for high throughput molecular (both microarray and sequencing) data, tissue related data, image data, and pharmacodynamics data (extended and new service);and 4) adapt and implement cohesive analysis and data mining tools that allow for integration and cross-validation of the comprehensive molecular data used in integrative cancer biology research (new service in 2008). The Facility has placed a high priority on integrating cancer research information representing a variety of data types, including clinical patient data, molecular data from microarrays, massive-parallel sequencers (e.g. Illumina [Solexa] Genome Analyzer) and RT-PCR, and image data from digitized microscopy slides. Data security is a primary focus of the Bioinformatics Facility in designing and implementing software systems. The Facility also provides computational bioinformatics support to assist in the analysis of genomic, molecular, and proteomic data using commercial and locally-developed software packages. Most recently, the facility has been re-located into newly renovated space (2,006 sq. ft.), providing a state-ofthe- art server room and expanded office and conference room space.

Public Health Relevance

Modern Cancer research creates large amount of data, much in digital forms. These data need to be managed, interpreted, and stored by qualified professionals who have an understanding of biology and computer sciences as well as adequate modern resources to carry out these functions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA010815-42
Application #
8233468
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
42
Fiscal Year
2011
Total Cost
$199,420
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
075524595
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Tomescu, Costin; Tebas, Pablo; Montaner, Luis J (2017) IFN-? augments NK-mediated antibody-dependent cellular cytotoxicity (ADCC) of HIV-1 infected autologous CD4+ T cells regardless of MHC-I downregulation. AIDS :
Vitiello, Marianna; Tuccoli, Andrea; D'Aurizio, Romina et al. (2017) Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells. Oncotarget 8:25395-25417
Veglia, Filippo; Gabrilovich, Dmitry I (2017) Dendritic cells in cancer: the role revisited. Curr Opin Immunol 45:43-51
Hoffman, Hunter; Rice, Cory; Skordalakes, Emmanuel (2017) Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes. J Biol Chem 292:4593-4601
Lu, Fang; Wiedmer, Andreas; Martin, Kayla A et al. (2017) Coordinate Regulation of TET2 and EBNA2 Control DNA Methylation State of Latent Epstein-Barr Virus. J Virol :
Karpel-Massler, Georg; Ishida, Chiaki Tsuge; Bianchetti, Elena et al. (2017) Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses. Cancer Res 77:3513-3526
Lynch, Shannon M; Mitra, Nandita; Ravichandran, Krithika et al. (2017) Telomere Length and Neighborhood Circumstances: Evaluating Biological Response to Unfavorable Exposures. Cancer Epidemiol Biomarkers Prev 26:553-560
Perales-Puchalt, Alfredo; Svoronos, Nikolaos; Rutkowski, Melanie R et al. (2017) Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target. Clin Cancer Res 23:441-453
Pestell, Timothy G; Jiao, Xuanmao; Kumar, Mukesh et al. (2017) Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth. Oncotarget 8:81754-81775
Noguchi, Shuhei; Arakawa, Takahiro; Fukuda, Shiro et al. (2017) FANTOM5 CAGE profiles of human and mouse samples. Sci Data 4:170112

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