During the last budget period, the Cancer Center has undergone an expansive reorganization of its administrative, scientific and educational goals and initiatives. Guided by a comprehensive and inclusive strategic planning process that engaged all ofthe stakeholders ofthe cancer research enterprise, comprehensive directives were implemented that realigned scientific Programs for multidisciplinary collaboration, reorganized Shared Resources for optimal impact and penetration, launched a portfolio of educational and mentoring initiatives and created inter-institutional partnerships along the continuum of basic, translational and patient-oriented cancer research. One of the key strategic directives of the consultative process was the creation of a dedicated administrative infrastructure ideally suited to guide the anticipated expansion ofthe Cancer Center during the next CCSG budget period, coinciding with the opening of the new Wistar Research Tower This resulted in the creation of a new Cancer Center leadership team, the reorganization of consultative and advisory venues, the appointment of new advisory committees, and the creation of a new Cancer Center-dedicated External Advisory Board. As emerged from the strategic planning process, this newly reconfigured, integrated administrative infrastructure provided a lean and opportunity-driven decision-making process for the Cancer Center. This was instrumental to enable a broad range of successful initiatives during the last budget period, which positioned the Cancer Center on a steep ascending trajectory with respect to growth of NCI and cancer-related funding, increase in collaborative publications and seminal scientific discoveries in basic and translational cancer research. This positive trajectory will continue in the next budget period, as the newly reconfigured Cancer Center administrative infrastructure will lead the upcoming faculty and facility expansion, expand education and mentoring activities, including outreach to underrepresented minorities, and support multidisciplinary initiatives in basic and translational cancer research

Public Health Relevance

In past CCSG budget periods, the Wistar Institute and its NCI-designated Cancer Center shared entirely their administrative infrastructure and decision-making venues. This has now changed as part ofthe comprehensive reorganization ofthe Cancer Center, and a dedicated administrative and leadership team is now in place to advance the cancer research agenda in the upcoming facility and faculty expansion

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Wistar Institute
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Tempera, Italo; De Leo, Alessandra; Kossenkov, Andrew V et al. (2016) Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte Survival. J Virol 90:345-55
Nelson, David M; Jaber-Hijazi, Farah; Cole, John J et al. (2016) Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol 17:158
Seo, Jae Ho; Rivadeneira, Dayana B; Caino, M Cecilia et al. (2016) The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol 14:e1002507
Haut, Larissa H; Gill, Amanda L; Kurupati, Raj K et al. (2016) A Partial E3 Deletion in Replication-Defective Adenoviral Vectors Allows for Stable Expression of Potentially Toxic Transgene Products. Hum Gene Ther Methods :
Peck, Barrie; Schug, Zachary T; Zhang, Qifeng et al. (2016) Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab 4:6
Chae, Young Chan; Vaira, Valentina; Caino, M Cecilia et al. (2016) Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming. Cancer Cell 30:257-72
Vazquez, Alexei; Kamphorst, Jurre J; Markert, Elke K et al. (2016) Cancer metabolism at a glance. J Cell Sci 129:3367-73
Kumar, Vinit; Patel, Sima; Tcyganov, Evgenii et al. (2016) The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment. Trends Immunol 37:208-20
Kung, Che-Pei; Murphy, Maureen E (2016) The role of the p53 tumor suppressor in metabolism and diabetes. J Endocrinol 231:R61-R75
Patro, Sean C; Azzoni, Livio; Joseph, Jocelin et al. (2016) Antiretroviral therapy in HIV-1-infected individuals with CD4 count below 100 cells/mm3 results in differential recovery of monocyte activation. J Leukoc Biol 100:223-31

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