The UAB Comprehensive Cancer Center is currently in its 39th year of continuous NCI CCSG funding. The Cancer Center has a well-established track record of translational research with a nnajor emphasis on investigator-initiated early phase 1 and II trials, many of which emanate from Cancer Center scientific discoveries. In addition, the Center has major strengths in the area of cancer health disparity research. Current funding levels are $106.1M total direct, $32.0M NCI, $48.2M other NIH, $8.7M peer-reviewed, and $17.1M non-peer reviewed. There are 244 members representing 10 schools and 33 departments. The Cancer Center's research enterprise is organized around seven programs, including three basic science programs - Tumor Immunology, Cancer Cell Biology, and Virology;two translational/dinical programs - Experimental Therapeutics and Neuro-Oncology;and two prevention and control programs - Cancer Chemoprevention and Cancer Control and Population Sciences. The Center's research enterprise is supported by 15 shared facilities that support and enhance our basic, clinical, translational, and prevention and control research by providing research technology, advanced genomics, biostatistics/bioinformatics, tissue procurement, human and animal imaging, and recruitment and retention of trial participants. Under current leadership, we have successfully recruited six new key leaders critical for a successful cancer research program and have recruited another 44 new cancer-focused faculty to various departments in the institution. Institutional support during this funding cycle has included $55M for recruitment and program building, $50M for renovation of cancer facilities including the Wallace Tumor Institute, the center of our cancer enterprise, and another $8.1 M from IMPACT funds to support recruitments. The Cancer Center has enhanced its translational research capabilities via a drug discovery and development initiative within the Experimental Therapeutics Program that incorporates the strength and resources of Southem Research into the Cancer Center via the Alabama Drug Discovery Alliance. In addition, the Cancer Center has forged a relationship with HudsonAlpha Institute for Biotechnology which provides the latest generation of high throughput genomic sequencing and collaborative expertise that will allow multiple programs to further understand the genetic footprints that impact therapeutic response, modify risk and thereby form the basis of individualized care.

Public Health Relevance

NCl-designated Comprehensive Cancer Centers are the centerpiece of the nation's effort to reduce cancer morbidity and mortality. The UAB Comprehensive Cancer Center serves as a major source for more effective approaches to prevention, diagnosis, treatment, and survivorship and as a source for delivery of these discoveries, public and professional education, and ultimately as a resource for the local, regional, and national community.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013148-42
Application #
8641324
Study Section
Subcommittee G - Education (NCI)
Program Officer
Silkensen, Shannon M
Project Start
1997-03-28
Project End
2016-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
42
Fiscal Year
2014
Total Cost
$4,779,754
Indirect Cost
$1,518,022
Name
University of Alabama Birmingham
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Carson, Tiffany L; Hardy, Claudia M; Greene, Eva et al. (2014) Considerations for bio-specimen collection among black women residing in the rural Deep South participating in a cancer prevention study. J Community Genet 5:257-63
Fauci, Janelle M; Sabbatino, Francesco; Wang, Yangyang et al. (2014) Monoclonal antibody-based immunotherapy of ovarian cancer: targeting ovarian cancer cells with the B7-H3-specific mAb 376.96. Gynecol Oncol 132:203-10
Devine, D J; Rostas, J W; Metge, B J et al. (2014) Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-*/SMAD signaling. Oncogene 33:2620-8
Kim, Hyunki; Rigell, Christopher J; Zhai, Guihua et al. (2014) Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers. Mol Imaging Biol 16:85-94
Saini, Reshu; Hoyt, Kenneth (2014) Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis. Imaging Med 6:41-52
Sonpavde, Guru; Willey, Christopher D; Sudarshan, Sunil (2014) Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma. Expert Opin Investig Drugs 23:305-15
Shim, Eun-Hee; Livi, Carolina B; Rakheja, Dinesh et al. (2014) L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov 4:1290-8
Gan, Yujun; Buckels, Ashiya; Liu, Ying et al. (2014) Human GH receptor-IGF-1 receptor interaction: implications for GH signaling. Mol Endocrinol 28:1841-54
Johnson, David H; Wilson, W William; DeLucas, Lawrence J (2014) Protein solubilization: a novel approach. J Chromatogr B Analyt Technol Biomed Life Sci 971:99-106
Ramos, Theresa N; Bullard, Daniel C; Barnum, Scott R (2014) ICAM-1: isoforms and phenotypes. J Immunol 192:4469-74

Showing the most recent 10 out of 364 publications