The primary objective of the Biostatistics and Bioinformatics Shared Facility (BBSF) is to provide centralized statistical services and collaborative research support for the research projects of the Cancer Center. To accomplish this, the BBSF has the following specific aims: 1) coordinate and manage statistical activities in the Cancer Center, ensuring that investigators have ready access to statistical consultation and support;2) provide data analysis for Cancer Center projects using contemporary statistical methodologies;3) provide statistical consultation on study design and research proposal development including pilot projects;4) participate in teaching and training activities of the Cancer Center;5) provide data management for the Clinical Protocol and Data Management (CPDM) Shared Facility including integration with OnCore;6) develop and manage SPORE databases;7) provide support for analysis of genetic data from UAB's Microarray Shared Facility and Hudson Alpha;8) maintain a data and information computing system integrated with the Cancer Center's Data Sharing Plan;9) develop methodologies for novel experimental designs and analyses that will enhance the BBSF's technical capabilities in providing collaborative research support. In addition to supporting the conventional needs of researchers, the BBSF has responded to the increasing role of multidimensional data analyses in mechanistic and functional studies using 'omic' technologies. The BBSF currently is composed of a team of faculty members and support staff from the Division of Preventive Medicine in the School of Medicine, and additional adjunct faculty from the Department of Biostatistics in the School of Public Health. By organizing as the BBSF they provide the Cancer Center investigators easy access to well-established and comprehensive biostatistical support in a very costeffective manner. The BBSF also has several integrative functions, as noted by the support for the SPOREfunded projects and the management of OnCore? for the Clinical Protocol and Data Management (CPDM) Shared Facility. Importantly, the BBSF also serves as a continuous point of contact with our partners, Morehouse School of Medicine and Tuskegee University, by providing regular support and training in research design as part of the Cancer Partnership. The success of the facility is evident through the high volume of publications for which the BBSF provided key support in research design and statistical analyses.

Public Health Relevance

In order to provide the most valid results, research studies should begin with good experimental design, be well managed, and end with appropriate analysis for the data. The BBSF serves as the focal point from which cancer center investigators draw the necessary statistical expertise for the design, management and analysis of cancer research projects. Through this work, the BBSF helps the CCC to achieve its goals to improve cancer prevention and outcomes.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Zhang, Wei; Zhai, Ling; Wang, Yimin et al. (2016) Discovery of a novel inhibitor of kinesin-like protein KIFC1. Biochem J 473:1027-35
Nebane, N Miranda; Coric, Tatjana; McKellip, Sara et al. (2016) Acoustic Droplet Ejection Technology and Its Application in High-Throughput RNA Interference Screening. J Lab Autom 21:198-203
Badiga, Suguna; Chambers, Michelle M; Huh, Warner et al. (2016) Expression of p16(INK4A) in cervical precancerous lesions is unlikely to be preventable by human papillomavirus vaccines. Cancer 122:3615-3623
Carvajal, Felipe; Vallejos, Maricarmen; Walters, Beth et al. (2016) Structural domains within the HIV-1 mRNA and the ribosomal protein S25 influence cap-independent translation initiation. FEBS J 283:2508-27
Hull, Travis D; Boddu, Ravindra; Guo, Lingling et al. (2016) Heme oxygenase-1 regulates mitochondrial quality control in the heart. JCI Insight 1:e85817
Zhang, Wei; Zhai, Ling; Lu, Wenyan et al. (2016) Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening. Chem Biol Drug Des 88:178-87
Smith, M Ryan; Vayalil, Praveen K; Zhou, Fen et al. (2016) Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels. Redox Biol 8:136-48
Hegde, Shylaja; Kesterson, Robert A; Srivastava, Om P (2016) CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation. PLoS One 11:e0149027
Styles, Nathan A; Shonsey, Erin M; Falany, Josie L et al. (2016) Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity. J Lipid Res 57:1133-43
McNally, Lacey R; Mezera, Megan; Morgan, Desiree E et al. (2016) Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology. Clin Cancer Res 22:3432-9

Showing the most recent 10 out of 566 publications