The Animal Barrier Shared Resource (ABSR) provides specific pathogen-free (SPF) rodent housing and services that are critical to the research of Albert Einstein Cancer Center (AECC) members and the Center's programmatic activities. The ABSR is a component of the Institute of Animal Studies (IAS), Einstein's AAALAC accredited animal care &use program. The ABSR provides a broad spectrum of animal husbandry services including: veterinary care, comprehensive rodent quality assurance and quarantine programs. There is an intensive program of instruction for AECC members and their trainees prior to allowing their access to the facilities to implement matings, genotype progeny, characterize mouse phenotypes, implant tumors and measure their growth, administer drugs, and obtain tissue biopsies. The capacity of the ABSR has been substantially increased since 2007 with the creation of a new SPF barrier facility in the Price Center that was opened in 2008 with a housing capacity of approximately 8,000 cages. With renovation and expansion of the two other existing facilities there is now an overall SPF mouse housing capacity of 25,000 cages. AECC members accounted for 58% of the total ABSR usage (cage care-days) and 47% of the maximum housing capacity of the resource during the reporting year (FYE'12). AECC investigators also account for 51% of mouse purchases and 54% of miscellaneous services provided by the ABSR /IAS. The IAS has an operating budget of over $7 M. Personnel expenses account for about 64% of the operating budget. IAS personnel include three faculty Laboratory Animal Veterinarians (including the Director), an Operations Manager, three Facility Supervisors, five Veterinary Technicians, office staff, and approximately 48 Animal Caretakers. The support requested in this application provides partial salary support for the ABSR Director, Operations manager, and Animal Facility Supervisors in each of the three main ABSR Facilities, and constitutes about 5% of total IAS personnel expenses.

Public Health Relevance

The Animal Barrier Shared Resource provides specific pathogen-free rodent housing and services that are critical to the translational research mission and goals of the Albert Einstein Cancer Center (AECC). As an NCI-designated Cancer Center, AECC contributes to the national effort to reduce morbidity and mortality from cancer.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30CA013330-41
Application #
8753335
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
41
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
City
Bronx
State
NY
Country
United States
Zip Code
10461
Oudin, Madeleine J; Hughes, Shannon K; Rohani, Nazanin et al. (2016) Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression. Clin Exp Metastasis 33:249-61
Lee, Chang-Hyun; Rimesso, Gerard; Reynolds, David M et al. (2016) Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster. G3 (Bethesda) 6:3207-3217
Lee, Kyeryoung; Tosti, Elena; Edelmann, Winfried (2016) Mouse models of DNA mismatch repair in cancer research. DNA Repair (Amst) 38:140-6
Díaz-Balzac, Carlos A; Rahman, Maisha; Lázaro-Peña, María I et al. (2016) Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites. Curr Biol 26:2379-87
Dam, Tarun K; Talaga, Melanie L; Fan, Ni et al. (2016) Measuring Multivalent Binding Interactions by Isothermal Titration Calorimetry. Methods Enzymol 567:71-95
Ito, Kyoko; Turcotte, Raphaël; Cui, Jinhua et al. (2016) Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354:1156-1160
Poulin, Myles B; Schneck, Jessica L; Matico, Rosalie E et al. (2016) Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36. Proc Natl Acad Sci U S A 113:1197-201
Yang, Chia-Ping Huang; Yap, Eng-Hui; Xiao, Hui et al. (2016) 2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes. Proc Natl Acad Sci U S A 113:11294-11299
Agalliu, Ilir; Gapstur, Susan; Chen, Zigui et al. (2016) Associations of Oral α-, β-, and γ-Human Papillomavirus Types With Risk of Incident Head and Neck Cancer. JAMA Oncol :
Epeldegui, Marta; Lee, Jeannette Y; Martínez, Anna C et al. (2016) Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial). Clin Cancer Res 22:328-36

Showing the most recent 10 out of 1310 publications