Based on the 2003 NCI review, and in consultation with CUMC and NYPH leadership,- and the newly constituted External Scientific.Advisory Board, the HICCC Director outlined a Strategic Plan to restructure and expand the Center.. The Plan included reshaping HICCC Leadership via internal promotions and recruitments and building active internal and external advisory bodies for the HICCC. This plan was successfully implemented with the recruitment of the Deputy Director for Clinical Research (Dr. E. Gelmann), the Associate Director for Biomedical Informatics (Dr. A. Califano), and the internal promotions of the Associate Director for Basic Research (Dr. R. Baer), the Associate Director for Shared Resources (Dr. Benjamin Tycko), and the Associate Director for Population Science (Dr. A. Neugut). In addition, three of the present seven HICCC Programs are led by newly nominated faculty. This reorganization of leadership has been accompanied by an overhaul of Planning and Evaluation and by the redesign of the HICCC's internal and external advisory bodies. The HICCC Director has the responsibility and authority to set priorities and to develop new Programs; nominate and retain scientific leaders and members;select programs, projects and members to receive pilot funding;allocate HICCC resources;'and organize the HICCC as a whole to promote productivity and scientific interactions. The Deputy Director for Clinical Research assists the HICCC Director in accomplishing these goals and in organizing the HICCC's clinical activities. The Director's decisions are based on input from the internal and external advisory bodies. The main internal advisory bodies include: i) the Senior Leadership Team;ii) the Internal Advisory Committee;iii) the Space Committee;iv) the Membership Committee;. and v) the Shared Resource Committee. The External Scientific Advisory Board (ESAB) has been reorganized in its leadership and composition, currently including 11 members representative of the major areas of HICCC research and administration. Funding in the amount of $16,500 is requested for the annual meeting of the ESAB.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
New York
United States
Zip Code
Bassuk, Alexander G; Sujirakul, Tharikarn; Tsang, Stephen H et al. (2014) A novel RPGR mutation masquerading as Stargardt disease. Br J Ophthalmol 98:709-11
Li, Yao; Wu, Wen-Hsuan; Hsu, Chun-Wei et al. (2014) Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects. Mol Ther 22:1688-97
Wert, Katherine J; Sancho-Pelluz, Javier; Tsang, Stephen H (2014) Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa. Hum Mol Genet 23:514-23
Shen, Sherry; Sujirakul, Tharikarn; Tsang, Stephen H (2014) Next-generation sequencing revealed a novel mutation in the gene encoding the beta subunit of rod phosphodiesterase. Ophthalmic Genet 35:142-50
Palomero, Teresa; Couronné, Lucile; Khiabanian, Hossein et al. (2014) Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet 46:166-70
Higuchi-Sanabria, Ryo; Pernice, Wolfgang M A; Vevea, Jason D et al. (2014) Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae. FEMS Yeast Res 14:1133-46
Lam, A T; Curschellas, C; Krovvidi, D et al. (2014) Controlling self-assembly of microtubule spools via kinesin motor density. Soft Matter 10:8731-6
Olszak, Torsten; Neves, Joana F; Dowds, C Marie et al. (2014) Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509:497-502
Murtomaki, Aino; Uh, Minji K; Kitajewski, Chris et al. (2014) Notch signaling functions in lymphatic valve formation. Development 141:2446-51
Nong, Eva; Lee, Winston; Merriam, Joanna E et al. (2014) Disease progression in autosomal dominant cone-rod dystrophy caused by a novel mutation (D100G) in the GUCA1A gene. Doc Ophthalmol 128:59-67

Showing the most recent 10 out of 142 publications