Koch Institute investigators have been pioneers in the use of animal models to study the molecular basis underlying the genesis and progression of cancer and are at the forefront of using animal modeling to address cancer detection and treatment. The Histology Core Facility has an outstanding histotechnology staff that provides cutting-edge histological expertise to all cancer researchers utilizing in vivo models. This expertise includes all aspects of histological analysis, from processing and sectioning to specialized staining and pathologic examination of tissue samples. Investigator training, from slide preparation to analysis, is another core component of this Core's mission. In addition, the Center continues to benefit from intellectual insight provided by veterinary pathologist, Dr. Roderick Bronson, an internationally recognized expert in mouse pathology. Dr. Bronson has made invaluable contributions to the characterization of developmental and tumor phenotypes, and has trained numerous Kl students, fellows and staff in histopathology. This has fostered exchange of intellectual expertise between Core staff and Center member laboratories and has played a significant role in strengthening the integrative nature of the Kl research program. Centralizing histological analyses under the auspices of the shared Histology Core allows us to capitalize on economies of scale and thereby provide cancer researchers a comprehensive and robust range of services. Over the current funding period, there has been a significant increase in the demand for these services, reflecting the broadening use of animal models by Center members. The Histology Core has responded to this need by increasing staff size and acquiring new instrumentation, which have enabled significantly greater and more efficient sample throughput. Accordingly, Core output in the immediate past funding year was substantially increased in all service categories in comparison to the last competing renewal. Based on continually increasing demand, additional service enhancements are planned for the requested funding period, which will allow us to expand both the usage and the Core Facility offerings without affecting the turnaround time for services.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts Institute of Technology
United States
Zip Code
Castellarnau, M; Szeto, G L; Su, H-W et al. (2015) Stochastic particle barcoding for single-cell tracking and multiparametric analysis. Small 11:489-98
Lunt, Sophia Y; Muralidhar, Vinayak; Hosios, Aaron M et al. (2015) Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell 57:95-107
Sukup-Jackson, Michelle R; Kiraly, Orsolya; Kay, Jennifer E et al. (2014) Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo. PLoS Genet 10:e1004299
Liu, Haipeng; Moynihan, Kelly D; Zheng, Yiran et al. (2014) Structure-based programming of lymph-node targeting in molecular vaccines. Nature 507:519-22
Chan, Ka Man Carmen; Li, Randolph H; Chapman, Joseph W et al. (2014) Functionalizable hydrogel microparticles of tunable size and stiffness for soft-tissue filler applications. Acta Biomater 10:2563-73
Meira, Lisiane B; Calvo, Jennifer A; Shah, Dharini et al. (2014) Repair of endogenous DNA base lesions modulate lifespan in mice. DNA Repair (Amst) 21:78-86
Pallasch, Christian P; Leskov, Ilya; Braun, Christian J et al. (2014) Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell 156:590-602
Murphy, Patrick A; Hynes, Richard O (2014) Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall. Arterioscler Thromb Vasc Biol 34:2042-50
Mayers, Jared R; Wu, Chen; Clish, Clary B et al. (2014) Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med 20:1193-8
Labelle, Myriam; Begum, Shahinoor; Hynes, Richard O (2014) Platelets guide the formation of early metastatic niches. Proc Natl Acad Sci U S A 111:E3053-61

Showing the most recent 10 out of 309 publications