Based on our experience, each new investigator requires approximately $1.5 million to establish an independent research program and obtain external support over an initial three-year period. The Institute guarantees to support the research programs of new investigators until they achieve independent support. We encourage new investigators to recruit postdoctoral fellows or graduate students, who are usually supported by Institute funds pending receipt of individual fellowships or other support. During the past five years (2003-2007) The Salk Institute invested more than $6.5 million (not including developmental funds from the CCSG) to establish the research programs of new investigators in the Cancer Center. (This amount does not include additional startup funds committed but not yet expended by recent appointees.) Support from CCSG developmental funds, although it was only a portion of the total required, was crucial in helping new appointees during the current funding period to establish and develop their independent research programs quickly and effectively. We anticipate that we will recruit one or two new investigators per year into the Cancer Center (this has been the average for the past several years). If each investigator requires two years to achieve independent funding, up to four investigators will require developmental support each year. We request funds to provide partial support for two investigators per year from the CCSG. As a result of an extensive review of Institute research programs over the past two years, several areas have been identified as high priorities for new faculty recruitment: biophotonics (advanced imaging), innate immunity, stem cell biology, metabolism, and inflammation biology. These areas will broaden and strengthen our cancer research program. We anticipate that two to three new faculty appointments will be made in each of these areas over the next several years, and that most of these new faculty members will become members of the Cancer Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Salk Institute for Biological Studies
La Jolla
United States
Zip Code
Evan, Gerard I; Hah, Nasun; Littlewood, Trevor D et al. (2017) Re-engineering the Pancreas Tumor Microenvironment: A ""Regenerative Program"" Hacked. Clin Cancer Res 23:1647-1655
Liu, Hao; Naxerova, Kamila; Pinter, Matthias et al. (2017) Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 23:5959-5969
Gasser, Emanuel; Moutos, Christopher P; Downes, Michael et al. (2017) FGF1 - a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol 13:599-609
Chen, Peiwen; Zuo, Hao; Xiong, Hu et al. (2017) Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A 114:580-585
Manoogian, Emily N C; Panda, Satchidananda (2017) Circadian rhythms, time-restricted feeding, and healthy aging. Ageing Res Rev 39:59-67
Fan, Weiwei; Waizenegger, Wanda; Lin, Chun Shi et al. (2017) PPAR? Promotes Running Endurance by Preserving Glucose. Cell Metab 25:1186-1193.e4
Tufail, Yusuf; Cook, Daniela; Fourgeaud, Lawrence et al. (2017) Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron 93:574-586.e8
Li, Dongming; Palanca, Ana Marie S; Won, So Youn et al. (2017) The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. Elife 6:
Wu, Min-Zu; Cheng, Wei-Chung; Chen, Su-Feng et al. (2017) miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. Nat Cell Biol 19:1286-1296
Doktorova, Marcela; Zwarts, Irene; Zutphen, Tim van et al. (2017) Intestinal PPAR? protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep 7:846

Showing the most recent 10 out of 429 publications