The scientific goals and central themes of the Mouse Models and Cancer Stem Cells Program are to investigate stem cell function, including self renewal and differentiation, growth factor requirements and microRNAs, using mouse, Drosophila, Xenopus, and zebrafish as models, with the goal of learning more about tissue and cancer stem cells. In addition, developmental signaling pathways that are known to be reactivated and drive the cancer cell phenotype, including the Wnt/p-catenin, ErbB2 and TAM receptor tyrosine kinases, and TGF-P pathways, are being studied. Genetic models are being developed and used to study cancer and inflammation. The program includes eleven members from six different laboratories: Senyon Choe (TGF-J3 receptor structure and signaling), Fred Gage (stem cell self renewal in the nervous system and cancer), Juan Carlos Izpisua Belmonte (tissue stem cell function in development and cancer), Leanne Jones (stem cell self renewal mechanisms), Chris Kintner (Notch pathway signaling in development), Kuo-Fen Lee (ErbB2 receptor tyrosine kinase signaling), Greg Lemke (TAM receptor tyrosine kinase signaling in the immune system), Samuel Pfaff (EphA receptor tyrosine kinase signaling in development), John Thomas (Drosophila glioblastoma model), InderVerma (mouse models of cancer and lentivirus vector development), and John Young (host cell factors in HTLV infection). The total amount of peer-reviewed support (direct costs) for the last budget year was $7,449,255. None of this was from direct NCI support. Substantial NIH and other federal support for this program is outlined in the table of externally funded research projects. The total number of publications by members of this program in the last grant period (2004-2008) was 299. Of the total publications, 10% were intraprogrammatic and 11 % were interprogrammatic (see Section 8 for explanation of how the program reorganization affects these numbers).

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Salk Institute for Biological Studies
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Aslanian, Aaron; Yates 3rd, John R; Hunter, Tony (2014) Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells. DNA Repair (Amst) 15:29-38
Lew, Erin D; Oh, Jennifer; Burrola, Patrick G et al. (2014) Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. Elife 3:
Chaix, Amandine; Zarrinpar, Amir; Miu, Phuong et al. (2014) Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab 20:991-1005
Xia, Yifeng; Shen, Shen; Verma, Inder M (2014) NF-?B, an active player in human cancers. Cancer Immunol Res 2:823-30
Islam, Md Soriful; Catherino, William H; Protic, Olga et al. (2014) Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function. J Clin Endocrinol Metab 99:E775-85
Evans, Ronald M; Mangelsdorf, David J (2014) Nuclear Receptors, RXR, and the Big Bang. Cell 157:255-66
Liu, Guang-Hui; Suzuki, Keiichiro; Li, Mo et al. (2014) Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nat Commun 5:4330
Buchwalter, Abigail L; Liang, Yun; Hetzer, Martin W (2014) Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol Biol Cell 25:2472-84
Hatori, Megumi; Gill, Shubhroz; Mure, Ludovic S et al. (2014) Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife 3:e03357
Korf, Katharina; Wodrich, Harald; Haschke, Alexander et al. (2014) The PML domain of PML-RAR? blocks senescence to promote leukemia. Proc Natl Acad Sci U S A 111:12133-8

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