The scientific goals and central themes of the Mouse Models and Cancer Stem Cells Program are to investigate different aspects of stem cell function, including self renewal, reprogramming, and dedifferentiation and differentiation, using mouse, Drosophila, Xenopus, and zebrafish as models, with the goal of learning more about embryonic, tissue and cancer stem cells. Linked to this are major efforts to use induced pluripotent stem cell (iPSC) technology to study mechanisms of genomic reprogramming, including changes in DNA methylation patterns, to learn how cancer stem cells might arise through genomic reprogramming, and to develop """"""""disease-in-a dish"""""""" models of human diseases. Developmental signaling pathways that are often reactivated and used to drive cancer cell phenotypes are being studied, including the Wnt/p-catenin pathway, the ERBB2, RET, and TAM receptor tyrosine kinases, and TGF-p pathways. The development and use of mouse models to study cancer biology and the role of inflammation in carcinogenesis are also important goals, and also to utilize lentivirus vectors for cancer therapy and for development of new cancer models. The program includes twelve members from eight different Laboratories (Departments), see the following page for a list of personnel. The NCI and other peer-reviewed cancer related support (direct costs) for the last budget year was $10,760,318. The substantial NIH and other federal support for this program is outlined in the table of externally funded research projects. The total number of cancer-relevant publications by members of this program in the last grant period (2008- 2012) was 237. Of the total publications, 7% were intraprogrammatic and 12% were interprogrammatic.

Public Health Relevance

The study of human cancer requires the development of animal models that recapitulate human disease. This program will focus on development of mouse models and stem cell approaches to studying cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA014195-41
Application #
8934260
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ciolino, Henry P
Project Start
2013-12-01
Project End
2018-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
41
Fiscal Year
2014
Total Cost
$39,041
Indirect Cost
$19,055
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Liu, Hao; Naxerova, Kamila; Pinter, Matthias et al. (2017) Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 23:5959-5969
Evan, Gerard I; Hah, Nasun; Littlewood, Trevor D et al. (2017) Re-engineering the Pancreas Tumor Microenvironment: A ""Regenerative Program"" Hacked. Clin Cancer Res 23:1647-1655
Chen, Peiwen; Zuo, Hao; Xiong, Hu et al. (2017) Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A 114:580-585
Gasser, Emanuel; Moutos, Christopher P; Downes, Michael et al. (2017) FGF1 - a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol 13:599-609
Fan, Weiwei; Waizenegger, Wanda; Lin, Chun Shi et al. (2017) PPAR? Promotes Running Endurance by Preserving Glucose. Cell Metab 25:1186-1193.e4
Manoogian, Emily N C; Panda, Satchidananda (2017) Circadian rhythms, time-restricted feeding, and healthy aging. Ageing Res Rev 39:59-67
Li, Dongming; Palanca, Ana Marie S; Won, So Youn et al. (2017) The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. Elife 6:
Tufail, Yusuf; Cook, Daniela; Fourgeaud, Lawrence et al. (2017) Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron 93:574-586.e8
Doktorova, Marcela; Zwarts, Irene; Zutphen, Tim van et al. (2017) Intestinal PPAR? protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep 7:846
Wu, Min-Zu; Cheng, Wei-Chung; Chen, Su-Feng et al. (2017) miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. Nat Cell Biol 19:1286-1296

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