The Bioinformatics Shared Resource, a core function of Duke Comprehensive Cancer:i_nstitute (DCCI}, supports the research needs of DCCI investigators (and secondarily, other Duke investigators) with respect to bioinformatics and complex data management and integration. Its mission is to provide a high-quality, service-oriented, coordinated, bioinformatics infrastructure for DCCI researchers, one.which increases collaborations across DCCI programs and between DCCI and other Duke programs.This core provides resources to DCCI programs and individual laboratories, coordinates institutional efforts in bioinformatics, helps drive the development of the biotechnology and pharmaceutical sectors withinDuke, and creates synergy between scientific and clinical groups. Services include state-of-the-art software to support a full range of research involving """"""""-omics"""""""" data, consultation and programming to assist with study design and analysis, CPU time for computationally intensive calculations, data storage, and training. The Resource coordinates its activities and directions closely with those of caBIG and NCI initiatives. in integrative research. The importance of the Bioinformatics Shared Resource within DCCI and at Duke has amplified with the explosion of genomic, proteomic, metabolomic, and other high-throughput data types;these data carry vast potential utility for clinical and translational research, especially when combined with Clinic l, imaging, and other scientific data. lni ially, this core focused on supporting DCCI studies involving DNA sequence and microarray gene expression data;we developed software and tools for visualization, c:tata mining, and annotation, first for individual research projects and then extrapolated for the general heds of genomics studies. Using microarray data as a starting point in a series of trials, we have honed our ability to integrate complex """"""""-omic"""""""" data into clinical trials. We have also developed caBIG infrastructure and tools, and controlled vocabularies. These capabilities, and our team which now possesses reqi..Jisite skills and experience, position us at the center of a distributed knowledge transfer system that links the DCCI, Institute or Genome Sciences and Policy, Shared Resources, and Duke Translational Medicifle Institute, and the caBIG infrastructure and National Bioinformatics Strategy. We have strengthened our role with each of these entities. The Bioinformatics Shared Resource functions as a service and knowledge vector through which we are transferring lessons learned in bioinformatics and """"""""-omic"""""""" sciences, and the benefits of new technological capabilities, to users across DCCI. Investigators spanning scientific disciplines that use high;.dimensional bioinformatics data (e.g., genomics, metabolomics, proteomics) can leverage our expertise to increase the uality and efficiency of complex, integrative, collaborative cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014236-40
Application #
8601855
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
40
Fiscal Year
2014
Total Cost
$205,736
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Galaz-Montoya, Monica; Wright, Sara J; Rodriguez, Gustavo J et al. (2017) ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem 292:9967-9974
Lanier, Megan L; Park, Hyeri; Mukherjee, Paramita et al. (2017) Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation. Chemistry 23:7180-7184
Shi, Qiong; Liu, Hongliang; Han, Peng et al. (2017) Genetic Variants in WNT2B and BTRC Predict Melanoma Survival. J Invest Dermatol 137:1749-1756
Woyach, Jennifer A; Ruppert, Amy S; Guinn, Daphne et al. (2017) BTKC481S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia. J Clin Oncol 35:1437-1443
Wang, Yanru; Freedman, Jennifer A; Liu, Hongliang et al. (2017) Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer. Int J Cancer 141:731-743
Fayanju, Oluwadamilola M; Hall, Carolyn S; Bauldry, Jessica Bowman et al. (2017) Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer. Am J Surg 214:666-671
Leu, David; Spasojevic, Ivan; Nguyen, Huy et al. (2017) CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5. Redox Biol 12:864-871
Sauer, Scott J; Tarpley, Michael; Shah, Imran et al. (2017) Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis 38:252-260
Pan, Yongchu; Liu, Hongliang; Wang, Yanru et al. (2017) Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep 7:44634
Yin, Jieyun; Liu, Hongliang; Liu, Zhensheng et al. (2017) Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Mol Carcinog 56:1663-1672

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