Abstract

The Data and Safety Monitoring System.(DSMS) of the UWCCC ensures that all clinical research beingconducted under the auspices of the UWCCC is in compliance with federal requirements and mostimportantly that human subject safety is always optimized. The DSMS is assisted in its mission of safety andcompliance by experienced UWCCC research staff, a Data and Safety Monitoring Committee (DSMC)composed of experienced clinical researchers, and the ongoing use of ONCORE database which allowsmore efficient tracking of protocols and protocol subjects. The DSMC reviews reports on quality assurance(internal audits, response reviews), protocol deviations and severe adverse events. The DSMC also providesdata review, data abstraction and entry, forms monitoring and final report generation for studies developedand solely monitored by the UWCCC. The DSMC is chaired and co-chaired by James Stewart, Professor ofMedicine, and KyungMann Kim, Professor of Biostatistics and Medical Informatics, each with > 20 years ofclinical trials experience.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA014520-34
Application #
7491903
Study Section
Subcommittee G - Education (NCI)
Project Start
2007-07-23
Project End
2012-03-31
Budget Start
2007-07-23
Budget End
2008-03-31
Support Year
34
Fiscal Year
2007
Total Cost
$114,366
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Schumacher, Jessica R; Neuman, Heather B; Chang, George J et al. (2018) A National Study of the Use of Asymptomatic Systemic Imaging for Surveillance Following Breast Cancer Treatment (AFT-01). Ann Surg Oncol 25:2587-2595
Turk, Anita A; Wisinski, Kari B (2018) PARP inhibitors in breast cancer: Bringing synthetic lethality to the bedside. Cancer 124:2498-2506
Liu, Ting; Shi, Changzheng; Duan, Linqi et al. (2018) A highly hemocompatible erythrocyte membrane-coated ultrasmall selenium nanosystem for simultaneous cancer radiosensitization and precise antiangiogenesis. J Mater Chem B 6:4756-4764
Zhan, Yonghua; Ehlerding, Emily B; Shi, Sixiang et al. (2018) Intrinsically Zirconium-89-Labeled Manganese Oxide Nanoparticles for In Vivo Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging. J Biomed Nanotechnol 14:900-909
Bloom, Debra D; Reshetylo, Sofiya; Nytes, Cassandra et al. (2018) Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity. J Immunother 41:213-223
Wei, Weijun; Jiang, Dawei; Ehlerding, Emily B et al. (2018) Noninvasive PET Imaging of T cells. Trends Cancer 4:359-373
Fricke, Stephanie L; Payne, Susan N; Favreau, Peter F et al. (2018) MTORC1/2 inhibition as a therapeutic strategy for PIK3CA mutant cancers. Mol Cancer Ther :
Feld, Shara I; Fan, Jun; Yuan, Ming et al. (2018) Utility of Genetic Testing in Addition to Mammography for Determining Risk of Breast Cancer Depends on Patient Age. AMIA Jt Summits Transl Sci Proc 2017:81-90
Hernández-Santos, Nydiaris; Wiesner, Darin L; Fites, J Scott et al. (2018) Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection. Cell Host Microbe 23:511-522.e5
van Ravesteyn, Nicolien T; van den Broek, Jeroen J; Li, Xiaoxue et al. (2018) Modeling Ductal Carcinoma In Situ (DCIS): An Overview of CISNET Model Approaches. Med Decis Making 38:126S-139S

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