For the past 29 years the Biostatistics Shared Resource (BSR) has played a vital role as an integral component in the research endeavor of the University of Wisconsin Carbone Cancer Center (UWCCC). Faculty members of the BSR are essential collaborative members in each of the eight Scientific Programs, from laboratory through translational to clinical and beyond in population science. The mission of the BSR is to promote excellence in cancer research at UWCCC by providing statisticians dedicated to offering outstanding biostatistical support and collaboration to UWCCC members. The hallmark of this Shared Resource has been collaboration with UWCCC members from the inception of research studies. BSR staff consult on developing the research design development, including selection of adequate study subjects;identification of suitable study endpoints;sample size estimation or power analysis;conduct and interim monitoring of studies;analysis of results for abstracts and presentation of research findings at scientific meetings;and preparation of final technical reports as a basis for scientific publications. The number of collaborative publications with UWCCC members attests to the excellence of the science supported through these collaborations and peer-reviewed projects and serves as a documentation of the BSR's contribution to the UWCCC research. This model of collaboration, instead of mere consultation with UWCCC members, has become a model not only for non-cancer biomedical research at the UW-Madison campus but also other NCI-designated cancer centers. The BSR continues to respond to the evolving needs of UWCCC by adding and realigning biostatistics faculty members and masters-level staff statisticians/data analysts to the BSR as needed, which avoids capacity issues. In turn, collaboration with UWCCC members feeds into the generation of ideas for new statistical methodology research and motivates statistical theory and methodology development. These new ideas can be applied to solving the original scientific questions with possible generalizations, thus completing the full cycle of collaboration and scientific interaction. This continues to serve as a model of very productive interactions at the UWCCC.

Public Health Relevance

The mission of the Biostatistics Shared Service (BSR) is to promote excellence in cancer research at UWCCC by providing statisticians who offer outstanding biostatistical support to UWCCC investigators. Faculty members of the BSR collaborate with members in each of the eight UWCCC Scientific Programs, ranging from laboratory to clinical to population science.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014520-40
Application #
8762774
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
40
Fiscal Year
2014
Total Cost
$276,764
Indirect Cost
$59,442
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Oberley, Christopher C; Bilger, Andrea; Drinkwater, Norman R (2015) Genetic background determines if Stat5b suppresses or enhances murine hepatocarcinogenesis. Mol Carcinog 54:959-70
Wisinski, Kari B; Ledesma, Wendy M; Kolesar, Jill et al. (2015) A phase I study to determine the maximum tolerated dose and safety of oral LR-103 (1?,24(S)Dihydroxyvitamin D2) in patients with advanced cancer. J Oncol Pharm Pract 21:416-24
Kolesar, Jill M; Pomplun, Marcia; Havighurst, Tom et al. (2015) Soy food frequency questionnaire does not correlate with baseline isoflavone levels in patients with bladder cancer. J Oncol Pharm Pract 21:128-31
Simoncic, Urban; Perlman, Scott; Liu, Glenn et al. (2015) Comparison of NaF and FDG PET/CT for assessment of treatment response in castration-resistant prostate cancers with osseous metastases. Clin Genitourin Cancer 13:e7-e17
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Chakravarty, Rubel; Hong, Hao; Cai, Weibo (2015) Image-Guided Drug Delivery with Single-Photon Emission Computed Tomography: A Review of Literature. Curr Drug Targets 16:592-609
Wu, Jianqiang; Salva, Katrin A; Wood, Gary S (2015) c-CBL E3 ubiquitin ligase is overexpressed in cutaneous T-cell lymphoma: its inhibition promotes activation-induced cell death. J Invest Dermatol 135:861-8
LoConte, Noelle K; Razak, Albiruni R A; Ivy, Percy et al. (2015) A multicenter phase 1 study of ? -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors. Invest New Drugs 33:169-76
Romens, Sarah E; McDonald, Jennifer; Svaren, John et al. (2015) Associations between early life stress and gene methylation in children. Child Dev 86:303-9
Nihal, Minakshi; Ahmad, Nihal; Wood, Gary S (2014) SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell Cycle 13:632-40

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