The Cell Signaling and Gene Regulation Program (Program 1) brings together a group of basic and translational investigators dedicated to the study of cancer through research in cell signaling, molecular biology, systems biology, developmental biology, and chemistry/drug discovery. The program has 46 members from 13 Departments, and members have a total of $16,459,487 in peer-reviewed funding with $5,012,818 from the NCI. Program members have been highly-productive, with 599 peer-reviewed publications, including 7% that were intraprogrammatic, and 15% interprogrammatic publications. The scientific goals of the Cell Signaling and Gene Regulation Program are to determine the basic cell signaling and gene expression mechanisms that underlie malignancy. To this end, our membership's research focuses on determining the mechanisms whereby genes, and the proteins they encode, function in both normal and cancerous conditions. In the previous funding period, Program 1 has increased its membership size from 25 to 46 members, reflecting a major recruitment of physician-scientists studying basic mechanisms of disease, as well as systems biologists. In addition, the UCCRC's outreach to physical scientists interested in collaborative interdisciplinary cancer research has also enriched the membership of Program 1. Overall, the research objectives of our scientists can be divided into the following five themes: (1) to elucidate the molecular mechanisms of tissue-specific and cell type-specific gene expression;(2) to elucidate the cellular mechanisms underlying cell growth/division and cell survival/death;(3) to understand the multi-faceted mechanisms leading to cancer metastases;(4) to use large-scale, high-throughput systems biology approaches and genetic evolutionary approaches to understand cancer biology;and (5) to discover novel developmental pathways relevant to cancer cell signaling. Although our members'interests are varied, many common themes have emerged. Moreover, in the current funding period, our membership has developed numerous collaborations with clinician scientists both within Program 1 and interprogramatically, reflecting the increasingly cross-disciplinary and translational nature of our research program. Through pilot funding, quarterly membership meetings, a seminar series, an annual retreat, and a strong basic science training program in cancer biology, Program 1 is poised to continue its successful in-depth and basic research focus on cancer biology, while nurturing collaborative science that will enhance clinical care of patients at risk or with cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-37
Application #
8375692
Study Section
Special Emphasis Panel (ZCA1-RTRB-N)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
37
Fiscal Year
2012
Total Cost
$36,474
Indirect Cost
$12,751
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Li, Gang; Montgomery, Jeffrey E; Eckert, Mark A et al. (2017) An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Nat Commun 8:1775
Stoddart, Angela; Wang, Jianghong; Hu, Chunmei et al. (2017) Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model. Blood 129:2959-2970
Wing, Claudia; Komatsu, Masaaki; Delaney, Shannon M et al. (2017) Application of stem cell derived neuronal cells to evaluate neurotoxic chemotherapy. Stem Cell Res 22:79-88
Shah, Palak; Trinh, Elaine; Qiang, Lei et al. (2017) Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules 22:
Qiang, Lei; Sample, Ashley; Shea, Christopher R et al. (2017) Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. Autophagy 13:2086-2103
Morita, Shuhei; Villalta, S Armando; Feldman, Hannah C et al. (2017) Targeting ABL-IRE1? Signaling Spares ER-Stressed Pancreatic ? Cells to Reverse Autoimmune Diabetes. Cell Metab 25:1207
Davis, Trevor L; Rebay, Ilaria (2017) Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina. Development 144:2640-2651
Kathayat, Rahul S; Elvira, Pablo D; Dickinson, Bryan C (2017) A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling. Nat Chem Biol 13:150-152
Hu, Xue; Li, Li; Yu, Xinyi et al. (2017) CRISPR/Cas9-mediated reversibly immortalized mouse bone marrow stromal stem cells (BMSCs) retain multipotent features of mesenchymal stem cells (MSCs). Oncotarget 8:111847-111865
Hasan, Yasmin; Waller, Joseph; Yao, Katharine et al. (2017) Utilization trend and regimens of hypofractionated whole breast radiation therapy in the United States. Breast Cancer Res Treat 162:317-328

Showing the most recent 10 out of 613 publications