The Cancer Prevention and Control (CPC) Program has undergone substantial growth and reorganization. It is an extremely interdisciplinary program involving 40 members from 12 Departments representing basic, translational, prevention and clinical investigators. Members have a total of $1 IM (annual direct costs) in peer-reviewed funding, including $4M from the NCI. During 2008-2011, CPC Program members generated a total of 473 peer-reviewed publications, including 16% intraprogrammatic, and 25% interprogrammatic publications. The overall goal of the Program is to promote novel cancer population science discoveries through interdisciplinary research, and to translate the knowledge into clinical and public health practice. The Program research spectrum is centered on understanding the determinants of major transition steps along the human health continuum, i.e., from the healthy state to the development of cancer, and then to cancer outcomes, as well as studying potential avenues of prevention. Thematically, the research themes are organized under two major themes: Theme 1) cancer risk and prevention;and Theme 2) cancer outcomes. The specific scientific objectives in Theme 1 are to: la) identify novel genomic, nutritional, and environmental determinants and their interactions in cancer risk;lb) identify the biological and behavioral basis for tobacco and alcohol use, and apply this knowledge to develop prevention and cessation-related treatment strategies;and Ic) examine biological and behavioral factors related to screening, early detection and prevention of cancer. The specific scientific objectives in Theme 2 are to: 2a) investigate the bio-behavioral, psychosocial and environmental determinants of cancer-related health outcomes, including survivorship;and 2b) examine cost-effectiveness and economic factors related to cancer diagnosis, treatment, and survivorship. As a cross-cutting theme, the majority of our Program members are focused on health disparities research in both local and global contexts. The CPC Program has well-established strengths in molecular, genetic and environmental epidemiology, biobehavioral and addiction research, as well as laboratory and preclinical studies in prevention sciences. A sub-theme on cancer outcomes, economics and survivorship research adds a new dimension to Program research by taking advantage of University of Chicago renowned strengths in economics and social sciences. Overall, the Program encompasses substantial transdisciplinary interactions and collaborations within and across programs.

Public Health Relevance

The CPC Program organizes, promotes and steers all cancer population and prevention research activities of the UCCCC. Members of this Program conduct research to understand the novel determinants of major transition steps along the human health continuum, i.e., from the healthy state to the development of cancer, and then to cancer outcomes, as well as studying potential avenues of prevention.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Chicago
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Johnson, Marianna B; Hoffmann, Joscelyn N; You, Hannah M et al. (2018) Psychosocial Stress Exposure Disrupts Mammary Gland Development. J Mammary Gland Biol Neoplasia 23:59-73
Sweis, Randy F; Zha, Yuanyuan; Pass, Lomax et al. (2018) Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer. J Immunother Cancer 6:24
Kathayat, Rahul S; Cao, Yang; Elvira, Pablo D et al. (2018) Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun 9:334
Liu, Jun; Eckert, Mark A; Harada, Bryan T et al. (2018) m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol 20:1074-1083
Bhanvadia, Raj R; VanOpstall, Calvin; Brechka, Hannah et al. (2018) MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease. Clin Cancer Res 24:3668-3680
Wood, Kevin; Byron, Elizabeth; Janisch, Linda et al. (2018) Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms. Am J Clin Oncol 41:963-966
Sample, Ashley; Zhao, Baozhong; Wu, Chunli et al. (2018) The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells. Photochem Photobiol 94:432-437
Hrusch, C L; Manns, S T; Bryazka, D et al. (2018) ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol 11:61-70
Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:
Wong, Gabrielle S; Zhou, Jin; Liu, Jie Bin et al. (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med 24:968-977

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