The Cancer Prevention and Control (CPC) Program has undergone substantial growth and reorganization. It is an extremely interdisciplinary program involving 40 members from 12 Departments representing basic, translational, prevention and clinical investigators. Members have a total of $1 IM (annual direct costs) in peer-reviewed funding, including $4M from the NCI. During 2008-2011, CPC Program members generated a total of 473 peer-reviewed publications, including 16% intraprogrammatic, and 25% interprogrammatic publications. The overall goal of the Program is to promote novel cancer population science discoveries through interdisciplinary research, and to translate the knowledge into clinical and public health practice. The Program research spectrum is centered on understanding the determinants of major transition steps along the human health continuum, i.e., from the healthy state to the development of cancer, and then to cancer outcomes, as well as studying potential avenues of prevention. Thematically, the research themes are organized under two major themes: Theme 1) cancer risk and prevention;and Theme 2) cancer outcomes. The specific scientific objectives in Theme 1 are to: la) identify novel genomic, nutritional, and environmental determinants and their interactions in cancer risk;lb) identify the biological and behavioral basis for tobacco and alcohol use, and apply this knowledge to develop prevention and cessation-related treatment strategies;and Ic) examine biological and behavioral factors related to screening, early detection and prevention of cancer. The specific scientific objectives in Theme 2 are to: 2a) investigate the bio-behavioral, psychosocial and environmental determinants of cancer-related health outcomes, including survivorship;and 2b) examine cost-effectiveness and economic factors related to cancer diagnosis, treatment, and survivorship. As a cross-cutting theme, the majority of our Program members are focused on health disparities research in both local and global contexts. The CPC Program has well-established strengths in molecular, genetic and environmental epidemiology, biobehavioral and addiction research, as well as laboratory and preclinical studies in prevention sciences. A sub-theme on cancer outcomes, economics and survivorship research adds a new dimension to Program research by taking advantage of University of Chicago renowned strengths in economics and social sciences. Overall, the Program encompasses substantial transdisciplinary interactions and collaborations within and across programs.

Public Health Relevance

The CPC Program organizes, promotes and steers all cancer population and prevention research activities of the UCCCC. Members of this Program conduct research to understand the novel determinants of major transition steps along the human health continuum, i.e., from the healthy state to the development of cancer, and then to cancer outcomes, as well as studying potential avenues of prevention.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of Chicago
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Feng, Christine H; Gerry, Emily; Chmura, Steven J et al. (2015) An image-guided study of setup reproducibility of postmastectomy breast cancer patients treated with inverse-planned intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys 91:58-64
Ming, Mei; Zhao, Baozhong; Shea, Christopher R et al. (2015) Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge. J Allergy Clin Immunol 135:936-45.e4
Ming, Mei; Zhao, Baozhong; Qiang, Lei et al. (2015) Effect of immunosuppressants tacrolimus and mycophenolate mofetil on the keratinocyte UVB response. Photochem Photobiol 91:242-7
Shah, Palak; He, Yu-Ying (2015) Molecular regulation of UV-induced DNA repair. Photochem Photobiol 91:254-64
Ming, Mei; Han, Weinong; Zhao, Baozhong et al. (2014) SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. Cancer Res 74:5925-33
Ramírez, Jacqueline; Kim, Tae Won; Liu, Wanqing et al. (2014) A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469. Pharmacogenet Genomics 24:129-32
Rudra, Sonali; Al-Hallaq, Hania A; Feng, Christine et al. (2014) Effect of RTOG breast/chest wall guidelines on dose-volume histogram parameters. J Appl Clin Med Phys 15:4547
Weng, Liming; Ziliak, Dana; Lacroix, Bonnie et al. (2014) Integrative "omic" analysis for tamoxifen sensitivity through cell based models. PLoS One 9:e93420
Stumpf, Melanie; Zhou, Xuyu; Chikuma, Shunsuke et al. (2014) Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function. Eur J Immunol 44:1737-46
Geeleher, Paul; Cox, Nancy J; Huang, R Stephanie (2014) Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol 15:R47

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