Pharmacology

Ratain, Mark J.

Abstract

The Pharmacology Core Facility (PCF) is a Shared Resource of the University of Chicago Medicine Comprehensive Cancer Center (UCCCC) that provides support to investigators conducting clinical pharmacology and biomarker research in the context of cancer clinical trials. Services offered include sample processing for studies requiring multiple and time-sensitive sampling, transmission of electrocardiograms (ECGs) on sponsored-provided machines for outpatients, collection and transmission of ECGs for inpatients, short-term sample storage, shipping, high-performance liquid chromatography (HPLC) assays, and pharmacokinetic analysis/modeling. Staff includes a Scientific Director, a Technical Director, five technologists and a financial administrator. The services are provided in a newly renovated Infusion Therapy Suite located across from the Hematology/Oncology Clinic in the Duchossois Center for Advanced Medicine (DCAM), and analytical laboratory space in the Knapp Center for Biomedical Discovery (KCBD). Currently, the PCF provides services for 278 cancer clinical studies at the University of Chicago, representing four of five UCCCC Research Programs (AI, CPC, IC, and CET) and 17 disease-site programs. The PCF will continue to support cancer investigators through processing, short-term storage, shipping and analysis of clinical samples, and will work with UCCCC leadership to identify and purchase a system for sample tracking/storage for real-time and simplified inventorying of samples.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Center Core Grants (P30)
• Project #: 5P30CA014599-44
• Application #: 9701144
• Study Section: Subcommittee I - Transistion to Independence (NCI)
• Budget Start: 2019-04-01
• Budget End: 2020-03-31
• Support Year: 44
• Fiscal Year: 2019

Institution

• Name: University of Chicago
• DUNS #: 005421136
• City: Chicago
• State: IL
• Country: United States
• Zip Code: 60637

Publications

Johnson, Marianna B; Hoffmann, Joscelyn N; You, Hannah M et al. (2018) Psychosocial Stress Exposure Disrupts Mammary Gland Development. J Mammary Gland Biol Neoplasia 23:59-73

Sweis, Randy F; Zha, Yuanyuan; Pass, Lomax et al. (2018) Pseudoprogression manifesting as recurrent ascites with anti-PD-1 immunotherapy in urothelial bladder cancer. J Immunother Cancer 6:24

Kathayat, Rahul S; Cao, Yang; Elvira, Pablo D et al. (2018) Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun 9:334

Liu, Jun; Eckert, Mark A; Harada, Bryan T et al. (2018) m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol 20:1074-1083

Bhanvadia, Raj R; VanOpstall, Calvin; Brechka, Hannah et al. (2018) MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease. Clin Cancer Res 24:3668-3680

Wood, Kevin; Byron, Elizabeth; Janisch, Linda et al. (2018) Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms. Am J Clin Oncol 41:963-966

Sample, Ashley; Zhao, Baozhong; Wu, Chunli et al. (2018) The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells. Photochem Photobiol 94:432-437

Hrusch, C L; Manns, S T; Bryazka, D et al. (2018) ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol 11:61-70

Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:

Wong, Gabrielle S; Zhou, Jin; Liu, Jie Bin et al. (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med 24:968-977