The Biostatistics Shared Resource (BSR) of the Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) plays a vital role in supporting research at the MCC. Faculty members in the BSR are essential collaborators with members of each of the research programs. The mission of the BSR is to promote excellence in cancer research at the MCC by supporting a biostatistics faculty dedicated to cancer research that provides outstanding biostatistical support and collaboration to MCC members. The defining attribute of the BSR has been to provide biostatistical support to the MCC researchers from the experimental design stage and to continue the support and guidance for sample size requirements and power calculations, study plan development, analysis ofthe requirement ofthe statistical design, development of randomization and stratification procedures, interim analyses, analysis of completed results, presentation of research findings, and, ultimately, in the submission of scientific publications. Biostatisticians also participate in the oversight of MCC clinical trials and research protocols through the Protocol Review and Monitoring Committee (PRMC) and additionally support the Data Safety and Monitoring Board (DSMB). The emphasis on the collaborative nature of the work of this shared resource has been a major factor in optimizing the effectiveness of the BSR and it has resulted in gaining support for peer-reviewed grants. In addition to collaboration at all levels in research projects and grant applications, faculty members of the BSR also contribute to the MCC through methodological research that applies directly to programmatic research at the MCC;and in training investigators through seminars and individual sessions, and postdoctoral scientists and clinical fellows through the Clinical Research and Biostatistics graduate degree concentration. Support from the Cancer Center Support Grant (CCSG) is critical to continued provision of high quality statistical input at the earliest phases of the research projects proposed and conducted at the MCC.
Statistical support provided through the Biostatistics Shared Resource is critical at all stages of basic, translational, and clinical cancer studies. High quality biostatistics support ensures that studies are designed in such a manner that they can answer the question being proposed, and it ensures that the conclusions of studies are supported by the data.
|Terracina, Krista P; Graham, Laura J; Payne, Kyle K et al. (2016) DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer. Cancer Immunol Immunother 65:1061-73|
|Ding, Boxiao; Parmigiani, Anita; Divakaruni, Ajit S et al. (2016) Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep 6:22538|
|Truchan, Hilary K; Cockburn, Chelsea L; Hebert, Kathryn S et al. (2016) The Pathogen-Occupied Vacuoles of Anaplasma phagocytophilum and Anaplasma marginale Interact with the Endoplasmic Reticulum. Front Cell Infect Microbiol 6:22|
|Alotaibi, Moureq; Sharma, Khushboo; Saleh, Tareq et al. (2016) Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Radiat Res 185:229-45|
|Agarwal, Stuti; Bell, Catherine M; Taylor, Shirley M et al. (2016) p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res 14:66-77|
|Menezes, M E; Das, S K; Minn, I et al. (2016) Detecting Tumor Metastases: The Road to Therapy Starts Here. Adv Cancer Res 132:1-44|
|Lafata, Jennifer Elston; Shay, L Aubree; Brown, Richard et al. (2016) Office-Based Tools and Primary Care Visit Communication, Length, and Preventive Service Delivery. Health Serv Res 51:728-45|
|Gewirtz, David A (2016) The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy. Cancer Res 76:5610-5614|
|Ge, Xiuchun; Shi, Xiaoli; Shi, Limei et al. (2016) Involvement of NADH Oxidase in Biofilm Formation in Streptococcus sanguinis. PLoS One 11:e0151142|
|Korwar, Sudha; Morris, Benjamin L; Parikh, Hardik I et al. (2016) Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP). Bioorg Med Chem 24:2707-15|
Showing the most recent 10 out of 413 publications