The Biostatistics Shared Resource (BSR) of the Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) plays a vital role in supporting research at the MCC. Faculty members in the BSR are essential collaborators with members of each of the research programs. The mission of the BSR is to promote excellence in cancer research at the MCC by supporting a biostatistics faculty dedicated to cancer research that provides outstanding biostatistical support and collaboration to MCC members. The defining attribute of the BSR has been to provide biostatistical support to the MCC researchers from the experimental design stage and to continue the support and guidance for sample size requirements and power calculations, study plan development, analysis ofthe requirement ofthe statistical design, development of randomization and stratification procedures, interim analyses, analysis of completed results, presentation of research findings, and, ultimately, in the submission of scientific publications. Biostatisticians also participate in the oversight of MCC clinical trials and research protocols through the Protocol Review and Monitoring Committee (PRMC) and additionally support the Data Safety and Monitoring Board (DSMB). The emphasis on the collaborative nature of the work of this shared resource has been a major factor in optimizing the effectiveness of the BSR and it has resulted in gaining support for peer-reviewed grants. In addition to collaboration at all levels in research projects and grant applications, faculty members of the BSR also contribute to the MCC through methodological research that applies directly to programmatic research at the MCC;and in training investigators through seminars and individual sessions, and postdoctoral scientists and clinical fellows through the Clinical Research and Biostatistics graduate degree concentration. Support from the Cancer Center Support Grant (CCSG) is critical to continued provision of high quality statistical input at the earliest phases of the research projects proposed and conducted at the MCC.

Public Health Relevance

Statistical support provided through the Biostatistics Shared Resource is critical at all stages of basic, translational, and clinical cancer studies. High quality biostatistics support ensures that studies are designed in such a manner that they can answer the question being proposed, and it ensures that the conclusions of studies are supported by the data.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Ginder, Gordon D (2015) Epigenetic regulation of fetal globin gene expression in adult erythroid cells. Transl Res 165:115-25
Chen, Shuang; Zhang, Yu; Zhou, Liang et al. (2014) A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis. Blood 124:2687-97
Youniss, Fatma M; Sundaresan, Gobalakrishnan; Graham, Laura J et al. (2014) Near-infrared imaging of adoptive immune cell therapy in breast cancer model using cell membrane labeling. PLoS One 9:e109162
Teves, Maria E; Sears, Patrick R; Li, Wei et al. (2014) Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat. PLoS One 9:e107271
Bie, Jinghua; Wang, Jing; Yuan, Quan et al. (2014) Liver-specific transgenic expression of cholesteryl ester hydrolase reduces atherosclerosis in Ldlr-/- mice. J Lipid Res 55:729-38
Teramachi, Jumpei; Zhou, Hua; Subler, Mark A et al. (2014) Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone. J Bone Miner Res 29:1456-65
Nakagawa, Akito; Lui, Francine E; Wassaf, Dina et al. (2014) Identification of a small molecule that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. ACS Chem Biol 9:2318-25
Sarkar, S; Azab, B; Quinn, B A et al. (2014) Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. Curr Mol Med 14:125-40
Dhall, Sandeep; Do, Danh; Garcia, Monika et al. (2014) A novel model of chronic wounds: importance of redox imbalance and biofilm-forming bacteria for establishment of chronicity. PLoS One 9:e109848
Rahmani, Mohamed; Aust, Mandy Mayo; Benson, Elisa C et al. (2014) PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo. Clin Cancer Res 20:4849-60

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