The Biostatistics Shared Resource (BSR) of the Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) plays a vital role in supporting research at the MCC. Faculty members in the BSR are essential collaborators with members of each of the research programs. The mission of the BSR is to promote excellence in cancer research at the MCC by supporting a biostatistics faculty dedicated to cancer research that provides outstanding biostatistical support and collaboration to MCC members. The defining attribute of the BSR has been to provide biostatistical support to the MCC researchers from the experimental design stage and to continue the support and guidance for sample size requirements and power calculations, study plan development, analysis of the requirement of the statistical design, development of randomization and stratification procedures, interim analyses, analysis of completed results, presentation of research findings, and, ultimately, in the submission of scientific publications. Biostatisticians also participate in the oversight of MCC clinical trials and research protocols through the Protocol Review and Monitoring Committee (PRMC) and additionally support the Data Safety and Monitoring Board (DSMB). The emphasis on the collaborative nature of the work of this shared resource has been a major factor in optimizing the effectiveness of the BSR and it has resulted in gaining support for peer-reviewed grants. In addition to collaboration at all levels in research projects and grant applications, faculty members of the BSR also contribute to the MCC through methodological research that applies directly to programmatic research at the MCC;and in training investigators through seminars and individual sessions, and postdoctoral scientists and clinical fellows through the Clinical Research and Biostatistics graduate degree concentration. Support from the Cancer Center Support Grant (CCSG) is critical to continued provision of high quality statistical input at the earliest phases of the research projects proposed and conducted at the MCC.

Public Health Relevance

Statistical support provided through the Biostatistics Shared Resource is critical at all stages of basic, translational, and clinical cancer studies. High quality biostatistics support ensures that studies are designed in such a manner that they can answer the question being proposed, and it ensures that the conclusions of studies are supported by the data.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee B - Comprehensiveness (NCI)
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Virginia Commonwealth University
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Ma, Yibao; Min, Hae-Ki; Oh, Unsong et al. (2017) The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals. J Biol Chem 292:20989-20997
van der Weyden, Louise; Arends, Mark J; Campbell, Andrew D et al. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature 541:233-236
Schurman, Lesley D; Smith, Terry L; Morales, Anthony J et al. (2017) Investigation of left and right lateral fluid percussion injury in C57BL6/J mice: In vivo functional consequences. Neurosci Lett 653:31-38
Newton, Jason; Hait, Nitai C; Maceyka, Michael et al. (2017) FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts. FASEB J 31:1719-1730
Manzanares, Miguel Á; Usui, Akihiro; Campbell, Deanna J et al. (2017) Transforming Growth Factors ? and ? Are Essential for Modeling Cholangiocarcinoma Desmoplasia and Progression in a Three-Dimensional Organotypic Culture Model. Am J Pathol 187:1068-1092
Arsenovic, Paul T; Mayer, Carl R; Conway, Daniel E (2017) SensorFRET: A Standardless Approach to Measuring Pixel-based Spectral Bleed-through and FRET Efficiency using Spectral Imaging. Sci Rep 7:15609
Lownik, Joseph C; Luker, Andrea J; Damle, Sheela R et al. (2017) ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. J Immunol 199:2305-2315
Karki, Kishor; Saraiya, Siddharth; Hugo, Geoffrey D et al. (2017) Variabilities of Magnetic Resonance Imaging-, Computed Tomography-, and Positron Emission Tomography-Computed Tomography-Based Tumor and Lymph Node Delineations for Lung Cancer Radiation Therapy Planning. Int J Radiat Oncol Biol Phys 99:80-89
Meier, Jeremy A; Hyun, Moonjung; Cantwell, Marc et al. (2017) Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production. Sci Signal 10:
Benson, Zachary; Manjili, Saeed H; Habibi, Mehran et al. (2017) Conditioning neoadjuvant therapies for improved immunotherapy of cancer. Biochem Pharmacol 145:12-17

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