-Rapid Case Ascertainment (RCA) Shared Resource Rapid Case Ascertainment (RCA) is a unique population science shared resource that provides central support for population-based research by providing rapid ascertainment of cancer cases that occur across North Carolina. Rapid case ascertainment (identification within one month after diagnosis) is critical to the successful conduct of quality, population-based, epidemiologic and outcomes studies, including studies that incorporate molecular biology, biomarkers, and patient-reported outcomes. Since it started in 1993, RCA supported multiple large population science research studies of breast, colon, prostate, head and neck cancers and melanoma. These included case-control etiologic studies and outcomes-related studies of bladder and prostate cancer. Built on decades of close collaboration with the State of North Carolina?s Central Cancer Registry (CCR) RCA facilitates efficient and centralized case identification. Because of its long-standing collaborative relationship with hospitals in North Carolina, RCA also works with LCCC members to collect baseline and follow-up medical records for enrolled patients. Finally, RCA provides consultation and administrative assistance to researchers through the coordination of grant applications, IRB approvals, reports to hospitals and tumor registrars, database development, and activities among project investigators, the State of North Carolina?s CCR, and related state committees. The RCA shared resource provides centralized coordination ascertainment, especially for hospitals in rural and underserved counties in the Center?s catchment area (all of North Carolina). Case-finding takes place for multiple studies across hospitals, providing a high degree of efficiency and cost effectiveness for the studies. In 2014, the facility was used to identify 16,366 new cases of breast, meningioma, prostate, cervical, colorectal, ovarian and medullary thyroid cancer cases across all 100 counties in North Carolina. A unique and valuable resource, RCA collaborated with other NCI Cancer Centers by supporting NC population research with other cancer centers in NC and outside the state. UNC Lineberger investigators continue to expand their efforts in population-based studies that rely on rapid case ascertainment. The RCA shared resource requests $73,090 in CCSG funds, representing 21% of its total budget. Future plans include the implementation of new NC population-based epidemiologic, clinical, and health services studies and working with the CCR to obtain additional follow-up on the occurrence of second primary tumors and the timely assessment of vital status of cases enrolled in epidemiologic and other population studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016086-40
Application #
8999671
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2016-03-24
Budget End
2016-11-30
Support Year
40
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Lim, Joseph K; Liapakis, Ann Marie; Shiffman, Mitchell L et al. (2018) Safety and Effectiveness of Ledipasvir and Sofosbuvir, With or Without Ribavirin, in Treatment-Experienced Patients With Genotype 1 Hepatitis C Virus Infection and Cirrhosis. Clin Gastroenterol Hepatol 16:1811-1819.e4
Wang, Gary P; Terrault, Norah; Reeves, Jacqueline D et al. (2018) Prevalence and impact of baseline resistance-associated substitutions on the efficacy of ledipasvir/sofosbuvir or simeprevir/sofosbuvir against GT1 HCV infection. Sci Rep 8:3199
Phillips, Bonnie; Van Rompay, Koen K A; Rodriguez-Nieves, Jennifer et al. (2018) Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques. J Virol 92:
Lianga, Noel; Doré, Carole; Kennedy, Erin K et al. (2018) Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset. PLoS Genet 14:e1007029
Allott, Emma H; Geradts, Joseph; Cohen, Stephanie M et al. (2018) Frequency of breast cancer subtypes among African American women in the AMBER consortium. Breast Cancer Res 20:12
Dhungel, Bal Mukunda; Montgomery, Nathan D; Painschab, Matthew S et al. (2018) 'Discovering' primary effusion lymphoma in Malawi. AIDS 32:2264-2266
Cameron, Jennifer E; Rositch, Anne F; Vielot, Nadja A et al. (2018) Epstein-Barr Virus, High-Risk Human Papillomavirus and Abnormal Cervical Cytology in a Prospective Cohort of African Female Sex Workers. Sex Transm Dis 45:666-672
Stanley, Christopher C; van der Gronde, Toon; Westmoreland, Kate D et al. (2018) Risk factors and reasons for treatment abandonment among children with lymphoma in Malawi. Support Care Cancer 26:967-973
Dronamraju, Raghuvar; Jha, Deepak Kumar; Eser, Umut et al. (2018) Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity. Nucleic Acids Res 46:1331-1344
Koehler, Jennifer W; Miller, Andrew D; Miller, C Ryan et al. (2018) A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma. J Neuropathol Exp Neurol 77:1039-1054

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