The Environmental and Molecular Carcinogenesis Program integrates 27 investigators (24 full members and 3 associate members) from several different departments on NYU campuses of Sterling Forest and the School of Medicine, sharing a common interest in understanding the Environmental causes of cancer. The overall goal of the Program is to understand the environmental etiology of cancer and to use this information for cancer prevention and early detection. The EMC Research Program focuses on the following goals: (1) Identifying the mechanisms of action for environmental carcinogens, with a strong focus on inorganic compounds, such as arsenic, nickel, chromium, and cadmium by investigating their effects on the structure and function of cellular macromolecules;(2) The formation of reactive oxygen species, their biochemistry, and the biological effects that might result from their cellular interactions;(3) The mutational specificity of carcinogens and the site-specific mutagenesis of particular DNA lesions, the molecular basis for genetic susceptibility to environmental agents, the effects of hormones on gene expression, carcinogenesis, and chemoprevention;and (4) Epigenetic mechanisms of carcinogenesis. To achieve these goals, research in this Program is divided thematically into four groups: 1) DNA adducts, DNA Damage and Repair;2) Carcinogenesis and Animal Models;3) Early Detection and Chemoprevention;and 4) Cell Signaling and Epigenetic Mechanisms of Carcinogenesis. Drs. Max Costa and William Rom are the Co-Leaders for this Program. Total funding decreased from $17,628,704 to $7,570,910 since the last competitive application. Membership has decreased from 47 to 28. Publications for the period total 323, of which 17% are intraprogrammatic, 16.1% are inter-programmatic, and 4% are both intra- and inter-programmatic collaborations.
The Environmental and Molecular Carcinogenesis Program integrates investigators whose research aims to understand the environmental etiology of cancer and to use this information for cancer prevention and early detection, with the ultimate goal of reducing the risk of cancer occurrence and death and improving the quality of life of cancer survivors.
|Chen, Danqi; Fang, Lei; Mei, Shenglin et al. (2018) Erratum: ""Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells"". Environ Health Perspect 126:019001|
|Fan, Xiaozhou; Peters, Brandilyn A; Jacobs, Eric J et al. (2018) Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults. Microbiome 6:59|
|Wadghiri, Youssef Z; Hoang, Dung Minh; Leporati, Anita et al. (2018) High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease. Sci Rep 8:7687|
|Khodadadi-Jamayran, Alireza; Akgol-Oksuz, Betul; Afanasyeva, Yelena et al. (2018) Prognostic role of elevated mir-24-3p in breast cancer and its association with the metastatic process. Oncotarget 9:12868-12878|
|Nancy, Patrice; Siewiera, Johan; Rizzuto, Gabrielle et al. (2018) H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest 128:233-247|
|Wang, Shiyang; Liechty, Benjamin; Patel, Seema et al. (2018) Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosis type 1 and 2 associated tumors. J Neurooncol 138:183-190|
|Ge, Wenzhen; Clendenen, Tess V; Afanasyeva, Yelena et al. (2018) Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts. Int J Cancer 142:2215-2226|
|Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242|
|Winer, Benjamin Y; Shirvani-Dastgerdi, Elham; Bram, Yaron et al. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med 10:|
|Ruggles, Kelly V; Wang, Jincheng; Volkova, Angelina et al. (2018) Changes in the Gut Microbiota of Urban Subjects during an Immersion in the Traditional Diet and Lifestyle of a Rainforest Village. mSphere 3:|
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