The Cancer Therapeutics Program membership includes clinical and basic science researchers whose shared focus is the translation of novel cancer therapies into new standards of care. This includes introduction of novel therapies developed in laboratories within the Abramson Cancer Center. In the period of the current report there has also been an initiative taken with one company (Pfizer) through which Penn investigators have obtained access to selected Pfizer compounds to pursue avenues of mutual interest that would not ordinarily rise to the priority within the company of receiving industry funding. Through this mechanism, the unexpected activity of an activating antibody directed to CD40 in pancreatic cancer has been discovered, as well as activity of a cdk 4/6-directed cell cycle inhibitor in two malignancies. The success of this collaboration is a constructive start to developing models for the optimal interaction of industry and academia in a time of intense scrutiny. For novel therapies that originate from industry sources in general, priority has been placed on the development of therapies for which Program members have scientific expertise regarding the pathways being perturbed or a research interest in defining responsive and refractory subpopulations.

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National Cancer Institute (NCI)
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Subcommittee G - Education (NCI)
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Qin, Jie; Rajaratnam, Rajathees; Feng, Li et al. (2015) Development of organometallic S6K1 inhibitors. J Med Chem 58:305-14
Couch, Fergus J; Nathanson, Katherine L; Offit, Kenneth (2014) Two decades after BRCA: setting paradigms in personalized cancer care and prevention. Science 343:1466-70
Maus, Marcela V; June, Carl H (2014) CARTs on the road for myeloma. Clin Cancer Res 20:3899-901
Al Zaki, Ajlan; Joh, Daniel; Cheng, Zhiliang et al. (2014) Gold-loaded polymeric micelles for computed tomography-guided radiation therapy treatment and radiosensitization. ACS Nano 8:104-12
Rosenfeld, Myrna R; Ye, Xiaobu; Supko, Jeffrey G et al. (2014) A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 10:1359-68
Mays, Lauren E; Wang, Lili; Lin, Jianping et al. (2014) AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Mol Ther 22:28-41
Noti, Mario; Kim, Brian S; Siracusa, Mark C et al. (2014) Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. J Allergy Clin Immunol 133:1390-9, 1399.e1-6
Zhang, Pingfeng; Leu, Julia I-Ju; Murphy, Maureen E et al. (2014) Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate. PLoS One 9:e103518
Seth, Asha; Ye, Jianming; Yu, Nanjia et al. (2014) Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development 141:538-47
Zhang, Liming; Zhu, Caixia; Guo, Yi et al. (2014) Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-J?. J Virol 88:6873-84

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