Small animals provide invaluable model systems in a broad range of disciplines in cancer research including cancer biology, genetics, immunology, stem cell biology, and experimental therapeutics. Effective utilization of these models often demands application of non-invasive imaging methodologies. These techniques allow for longitudinal studies of disease progression and response to therapy as well as providing unique information that is not accessible via other methodologies, The major impediment to the application of these methodologies is that the highly specialized instrumentation and diverse expertise necessary is generally beyond the reach of the individual PI. The Small Animal Imaging Core (SAIC) is a shared resource within the Abramson Cancer Center (ACC) that serves researchers within ACC, the university and surrounding institutions. The core provides state of the art instrumentation and a renowned support staff with the expertise necessary to apply a broad range of imaging modalities to small animal models. Supported modalities include magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), single photon emission computed tomography (SPECT), ultrasound imaging (US) and bioluminescence imaging (to detect luciferase and green fluorescent protein). Each imaging modality is supported by a faculty Director with extensive experience in the application and development of the corresponding imaging modality to small animals. In addition, the SAIC provides limited animal housing for rats and mice allowing multiple imaging sessions to be performed on a particular animal over an extended period without risking infection of the general population of animals. The facility also provides support for data transfer and analysis. Over 25 ACC members have used the core in the last year. ACC member usage was 53% of the total core usage. CCSG support represents 28% of the proposed core budget with the remaining funding coming from charge backs and institutional support.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016520-38
Application #
8593276
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
38
Fiscal Year
2014
Total Cost
$208,895
Indirect Cost
$86,401
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Qin, Jie; Rajaratnam, Rajathees; Feng, Li et al. (2015) Development of organometallic S6K1 inhibitors. J Med Chem 58:305-14
Couch, Fergus J; Nathanson, Katherine L; Offit, Kenneth (2014) Two decades after BRCA: setting paradigms in personalized cancer care and prevention. Science 343:1466-70
Maus, Marcela V; June, Carl H (2014) CARTs on the road for myeloma. Clin Cancer Res 20:3899-901
Al Zaki, Ajlan; Joh, Daniel; Cheng, Zhiliang et al. (2014) Gold-loaded polymeric micelles for computed tomography-guided radiation therapy treatment and radiosensitization. ACS Nano 8:104-12
Noti, Mario; Kim, Brian S; Siracusa, Mark C et al. (2014) Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. J Allergy Clin Immunol 133:1390-9, 1399.e1-6
Rosenfeld, Myrna R; Ye, Xiaobu; Supko, Jeffrey G et al. (2014) A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 10:1359-68
Mays, Lauren E; Wang, Lili; Lin, Jianping et al. (2014) AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Mol Ther 22:28-41
Zhang, Liming; Zhu, Caixia; Guo, Yi et al. (2014) Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-J?. J Virol 88:6873-84
Bhattacharya, Sabyasachi; Katlinski, Kanstantsin V; Reichert, Maximilian et al. (2014) Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury. EMBO Mol Med 6:384-97
Zhang, Pingfeng; Leu, Julia I-Ju; Murphy, Maureen E et al. (2014) Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate. PLoS One 9:e103518

Showing the most recent 10 out of 193 publications