The Tissue Biospecimen and Pathology Resource (TBPR) is comprised of mature, highly functional CCSG supported shared facilities and provides all basic science, translational, clinical, and population science investigators at MD Anderson with access to human tissues that have been removed by therapeutic resection or biopsy with research consent, and advanced histologic services for characterization of human and animal research tissues. The TBPR supports hypothesis-generating, -developing, and -testing studies, including both correlative and integrated marker studies in clinical trials. The TBPR biorepository has six -80 freezers and three isothermal liquid nitrogen freezers in its centralized and monitored storage facility, and a - 80 freezer in each of the two Surgical Pathology suites. The TBPR research histology core includes specialized equipment for immunohistochemistry, fluorescent in situ hybridization (FISH), laser capture microdissection, and tissue microarray construction. 190,235 tissue specimens from 37,296 cases were collected during the current reporting period for Yrs 33-38, and 63,288 specimens were distributed to 152 investigators. Research histology usage grew by 5.2% from 174,015 units in 2007-2008 to 183,134 in 2011- 2012. Of the 152 total individual users of the TBPR biorepository, 86% of users had peer-reviewed funding, and 81.2% of 422 TBPR research histology users had peer-reviewed funding. 42% of the total operating budget for the TBPR is requested from the CCSG. Publications cited using the CCLC have appeared in Nature, Nature Med and J Clin Oncol. Institutional administrative support was provided by the Research Support Office in the Division of Pathology &Laboratory Medicine. Future plans include: establishing collaborative efforts with Lyndon B. Johnson Hospital and Banner MD Anderson to increase specimen collections from underserved and community patient populations;increasing sterile tissue collection and processing for vaccine clinical trials;increasing specimen collection in clinic procedure rooms and Interventional Radiology;collaborating with the Office of Biorepository Regulatory Support to standardize operations in all federated biorepositories at MD Anderson;enhancing Tissue Station integration with clinical and research protocol management databases;increasing the roster of available tissue biomarkers;and implementing a more efficient and multifunctional Laboratory Information Management System for charge backs, inventory monitoring, and workload reporting.

Public Health Relevance

The maintenance of a flexible, sophisticated institutional biorepository in conjunction with an advanced research histology core facility is vital to all aspects of current and future intra- and extramural clinical, translational, basic, and population-based research efforts at MD Anderson.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016672-39
Application #
8759780
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
39
Fiscal Year
2014
Total Cost
$797,780
Indirect Cost
$299,378
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Torres, Harrys A; Hosry, Jeff; Mahale, Parag et al. (2018) Hepatitis C virus reactivation in patients receiving cancer treatment: A prospective observational study. Hepatology 67:36-47
Parra, Edwin R; Villalobos, Pamela; Behrens, Carmen et al. (2018) Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches. J Immunother Cancer 6:48
Yin, Guosheng; Chen, Nan; Lee, J Jack (2018) Bayesian Adaptive Randomization and Trial Monitoring with Predictive Probability for Time-to-event Endpoint. Stat Biosci 10:420-438
Nong, Jingying; Gong, Yuhua; Guan, Yanfang et al. (2018) Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer. Nat Commun 9:3114
Brown, Justin C; Rickels, Michael R; Troxel, Andrea B et al. (2018) Dose-response effects of exercise on insulin among colon cancer survivors. Endocr Relat Cancer 25:11-19
Vakil, Erik; Jimenez, Carlos A; Faiz, Saadia A (2018) Pleural effusions in hematologic malignancies and their management with indwelling pleural catheters. Curr Opin Pulm Med 24:384-391
Yedururi, Sireesha; Chawla, Sumedha; Amini, Behrang et al. (2018) Tumor thrombus in the large veins draining primary pelvic osteosarcoma on cross sectional imaging. Eur J Radiol 105:49-55
Farinholt, Paige; Park, Minjeong; Guo, Ying et al. (2018) A Comparison of the Accuracy of Clinician Prediction of Survival Versus the Palliative Prognostic Index. J Pain Symptom Manage 55:792-797
Oh, Sang Cheul; Sohn, Bo Hwa; Cheong, Jae-Ho et al. (2018) Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun 9:1777
Yang, Yi; Li, Chia-Wei; Chan, Li-Chuan et al. (2018) Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res 28:862-864

Showing the most recent 10 out of 12418 publications