The Cancer Prevention and Control Program (CPCP) is a productive and interactive multi-disciplinary team of 19 investigators, including 17 Full and two Associate Qunior mentored) Members drawn from 7 academic departments. The goal of the CPCP is to conduct innovative and high impact research in childhood cancer prevention and control through an integrated program encompassing outcomes and intervention research. Using institutional and national CPCP-led research resources consisting of the St. Jude Lifetime (SJLIFE) cohort, the Childhood Cancer Survivor Study (CCSS) cohort, and the St. Jude Consortium for Pediatric Intervention Research (CPIR), program members are conducting cancer survivorship-based research to describe the occurrence and pathogenesis of physiological and psychological long-term outcomes associated with the diagnosis and treatment of cancer during childhood and adolescence. A central theme of the CPCP is to translate findings from clinical and observational research into clinical practice or intervention trials designed to prevent or ameliorate the acute and long-term morbidity of treatment and improve quality of life. To. this end, the Program is organized around three principal areas of Research Emphasis: (1) Identification of High-Risk Groups and Insights into the Mechanisms of Treatment-related Outcomes. (2) Translation of Observational Research into Clinical Practice. (3) Translation of Observational Research into Intervention Trials Insights The CPCP relies heavily upon the Cancer Center's Biostatistics, Molecular Therapeutic Clinical Trials, and Hartwell Center shared resources. CPCP members are actively engaged in numerous protocol-specific collaborations with other Cancer Center programs. The CPCP membership is supported by $8.0 million in cancer-related funding ($7.9 million peer-reviewed;$0.1 million non-peer reviewed) and has published 406 papers of which 27% (n=110/406) were intraprogrammatic and 26% (n=104/406) were interprogrammatic.
Almost 80% of U.S. children with cancer now survive beyond 5 years from diagnosis. These improved outcomes have resulted in a growing population of childhood cancer survivors, now estimated to number more than 370,000. This population is at increased risk for a variety of health problems. CPCP investigators are conducting research to further define the occurrence of, and risk factors for;these adverse late outcomes in order to develop intervention approaches that improve the quality of life of childhood cancer survivors.
|Wu, Jianrong (2015) Power and sample size for randomized phase III survival trials under the Weibull model. J Biopharm Stat 25:16-28|
|Serinagaoglu, Yelda; Paré, Joshua; Giovannini, Marco et al. (2015) Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol 398:97-109|
|Kimberg, Cara I; Klosky, James L; Zhang, Nan et al. (2015) Predictors of health care utilization in adult survivors of childhood cancer exposed to central nervous system-directed therapy. Cancer 121:774-82|
|Bhojwani, Deepa; McCarville, Mary B; Choi, John K et al. (2015) The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol 168:845-53|
|Chamdine, Omar; Gaur, Aditya H; Broniscer, Alberto (2015) Effective treatment of cerebral mucormycosis associated with brain surgery. Pediatr Infect Dis J 34:542-3|
|Karol, Seth E; Coustan-Smith, Elaine; Cao, Xueyuan et al. (2015) Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. Br J Haematol 168:94-101|
|Chan, W K; Suwannasaen, D; Throm, R E et al. (2015) Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity. Leukemia 29:387-95|
|Gawade, Prasad L; Oeffinger, Kevin C; Sklar, Charles A et al. (2015) Lifestyle, distress, and pregnancy outcomes in the Childhood Cancer Survivor Study cohort. Am J Obstet Gynecol 212:47.e1-10|
|Momani, Tha'er G; Mandrell, Belinda N; Gattuso, Jami S et al. (2015) Children's perspective on health-related quality of life during active treatment for acute lymphoblastic leukemia: an advanced content analysis approach. Cancer Nurs 38:49-58|
|Dodd, K; Nance, S; Quezada, M et al. (2015) Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity. Oncogene 34:1312-22|
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