The Hematological Malignancies Program (HMP) continues a long tradition of leukemia and lymphoma research in the St. Jude Children's Research Hospital Comprehensive Cancer Center (SJCCC), facilitating interdisciplinary collaborations among basic, translational and clinical research investigators. The HMP has 27 Full members, and one Associate (junior mentored) member, drawn from seven departments. The overall goal of the Program is to advance cures for children with leukemia, while minimizing acute and long-term side effects of therapy. To this end, the Program conducts multi-disciplinary research across the full spectrum of basic science, translational and clinical research: (1) Basic Science Research within the HMP aims to identify and characterize the key genetic alterations that underlie childhood hematological malignancies, and to determine the potential of these alterations to serve as therapeutic targets. This group also studies the biology of bone marrow transplantation. (2) Translational Research focuses on defining genetic determinants of disease risk, drug pharmacology;efficacy and toxicity. This group also builds on genomic and transplant discoveries made in the Basic Science Group to develop innovative tools to classify leukemia, detect minimal residual disease, and treat hematologic malignancies. (3) Clinical Research within the HMP serves as the final step to translate basic science discoveries to the clinic. To this end the group conducts large, single-institution or multi-center clinical trials to advance cures for childhood leukemia, including trials of molecular targeted and cell transplant-based therapies. Members also collaborate with experts in the Cancer Prevention and Control Program to define and mitigate treatment late effects. For many years the members of the HMP have played leading and collaborative roles in the national consortia including the NCI-Children's Oncology Group (COG). The HMP benefits from strong extramural funding that totals $14.3 million in cancer-related awards ($10.4 million peer-reviewed;$3.9 million non-peer reviewed sources). The HMP is also a highly productive Program, publishing 469 manuscripts during the last funding period (30%, intraprogrammatic;28%, interprogrammatic).

Public Health Relevance

Leukemia is the most common pediatric malignancy, accounting for one third of all childhood cancers. Despite steady increases in the overall cure rate for leukemias, significant numbers of children still suffer relapsed or refractory disease, and many have unacceptable treatment-related toxicities. Therefore, by translating basic understanding of leukemia biology to the clinic, the HMP strives to improve the use of existing therapies, discover new treatments for resistant disease, and reduce late effects of therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA021765-35
Application #
8634429
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-04-01
Project End
2019-02-28
Budget Start
2014-06-09
Budget End
2015-02-28
Support Year
35
Fiscal Year
2014
Total Cost
$653,591
Indirect Cost
$283,017
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
ElInati, Elias; Russell, Helen R; Ojarikre, Obah A et al. (2017) DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line. Proc Natl Acad Sci U S A 114:12536-12541
Gibson, Todd M; Li, Zhenghong; Green, Daniel M et al. (2017) Blood Pressure Status in Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study. Cancer Epidemiol Biomarkers Prev 26:1705-1713
Scott, Daniel C; Hammill, Jared T; Min, Jaeki et al. (2017) Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat Chem Biol 13:850-857
Patel, Y T; Daryani, V M; Patel, P et al. (2017) Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas. CPT Pharmacometrics Syst Pharmacol 6:305-314
Penkert, Rhiannon R; Jones, Bart G; H├Ącker, Hans et al. (2017) Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines. Cytokine 91:1-5
Howell, Carrie R; Wilson, Carmen L; Ehrhardt, Matthew J et al. (2017) Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study. Cancer :
Talleur, Aimee C; Triplett, Brandon M; Federico, Sara et al. (2017) Consolidation Therapy for Newly Diagnosed Pediatric Patients with High-Risk Neuroblastoma Using Busulfan/Melphalan, Autologous Hematopoietic Cell Transplantation, Anti-GD2 Antibody, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-2, and Hapl Biol Blood Marrow Transplant 23:1910-1917
Wu, Jianrong (2017) Single-Arm Phase II Survival Trial Design Under the Proportional Hazards Model. Stat Biopharm Res 9:25-34
Svolos, P; Reddick, W E; Edwards, A et al. (2017) Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation. AJNR Am J Neuroradiol 38:1235-1241
Lin, Wenwei; Goktug, Asli N; Wu, Jing et al. (2017) High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor. Assay Drug Dev Technol 15:383-394

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