The Karmanos Cancer Institute requests funds for five Staff Investigators. These five individuals link investigators from different Programs to focus on specific translational areas of research and education and mentoring. The mentorship role of senior investigators is of particular importance in aiding the growth of young scientists. Four of these Staff Investigators provide invaluable mentorship for selected Research Teams. Dr. Shirish Gadgeel (Developmental Therapeutics) is Co-Leader of the Lung Cancer Research Team. Dr. Elisabeth Heath (Developmental Therapeutics) is Leader of the Prostate Cancer Research Team. Dr. Lawrence Lum (Breast Cancer Biology joint with Developmental Therapeutics) is Co-Leader of the Tumor Immunology Research Team. Dr. Larry Matherly (Developmental Therapeutics) is Co-Leader of the Leukemia/Lymphoma Research Team and also leads our Cancer Biology Graduate Program. These four Research Team leaders coordinate research efforts and organize meetings. They encourage inter- and intra-programmatic collaborations with the goal of identifying opportunities for program projects and imminent translation to patient care. They partner with Program Leaders and Research Administration to learn of opportunities for seed funding and pilot projects and integrate these opportunities into the activities and priorities of their respective Research Teams. Infrastructure support, such as IT requirements and meeting preparation, are coordinated by these team leaders. Dr. Avraham Raz (Proteases and Cancer) is proposed as a Staff Investigator in light of his extensive experience and exceptional success in mentoring and advising young and established scientists. In particular, he fosters, advises, mentors, and directs junior scientists toward obtaining independent and collaborative funding. Funding for each of these Staff Investigators is requested at 10% effort.

Public Health Relevance

; Five scientists have been selected to serve as Staff Investigators. Four of these Leaders are chosen to support their activities on their respective Research Teams. The fifth scientist is proposed to support his mentoring and advising activities on behalf of junior scientists.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Wayne State University
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Ratanatharathorn, V; Deol, A; Ayash, L et al. (2015) Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT. Bone Marrow Transplant 50:106-12
Bollig-Fischer, Aliccia; Chen, Wei; Gadgeel, Shirish M et al. (2015) Racial diversity of actionable mutations in non-small cell lung cancer. J Thorac Oncol 10:250-5
Motzer, Robert J; Rini, Brian I; McDermott, David F et al. (2015) Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial. J Clin Oncol 33:1430-7
Wijesinghe, Priyanga; Bepler, Gerold; Bollig-Fischer, Aliccia (2015) A mass spectrometry assay to simultaneously analyze ROS1 and RET fusion gene expression in non-small-cell lung cancer. J Thorac Oncol 10:381-6
Koo, Imhoi; Yao, Sen; Zhang, Xiang et al. (2014) Comparative analysis of false discovery rate methods in constructing metabolic association networks. J Bioinform Comput Biol 12:1450018
Koo, Imhoi; Wei, Xiaoli; Shi, Xue et al. (2014) Constructing Metabolic Association Networks Using High-dimensional Mass Spectrometry Data. Chemometr Intell Lab Syst 138:193-202
Heng, D Y C; Choueiri, T K; Rini, B I et al. (2014) Outcomes of patients with metastatic renal cell carcinoma that do not meet eligibility criteria for clinical trials. Ann Oncol 25:149-54
Szalai, Gabor; Xu, Yi; Romero, Roberto et al. (2014) In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy. PLoS One 9:e110867
Bengsch, F; Buck, A; Gunther, S C et al. (2014) Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene 33:4474-84
Speyer, Cecilia L; Hachem, Ali H; Assi, Ali A et al. (2014) Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer. PLoS One 9:e88830

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