9.1.12 BIOMETRY SHARED SERVICE The Biometry Shared Service (BSS) brings together expertise in biostatistics, clinical trials, epidemiology, applied mathematics, statistical computing, and database applications. Personnel in the BSS have wide-ranging involvement across the research activities ofthe Arizona Cancer Center (AZCC), including clinical, translational, basic, and population-based research. Biostatistical collaboration and consultation have been provided for investigators in each of the five Scientific Programs in the AZCC. As an example, for the period July 2006 - June 2008, Biometry personnel supported 62 AZCC Program Member investigators. The BSS is active in all phases of study design, operation, data management, statistical analysis, and manuscript preparation. Provided services include: 1) protocol development;2) review of Cancer Center protocols;3) data analysis and reporting;4) statistical database applications;5) data services and computer programming;6) education and training;and 7) statistical consultation and collaboration. Biostatisticians from the BSS are members of the Scientific Review Committee, which reviews Cancer Center patient protocols before activation to ensure appropriate scientific content. DUring the current funding period, biostatisticians have been co-authors on approximately 80 papers published by AZCC investigators. Additionally, 170 technical reports have been generated to document statistical analyses and their interpretation. Recruitment activities in Biometry are enhancing the breadth of biostatistical support of Cancer Center activities, allowing the fostering of the philosophy that productive research requires high quality biostatistical collaboration. Biometry faculty have had significant success in attracting funding for biostatistics-related Cores in a number of long-term research projects in the AZCC;in addition, BSS biostatisticians serve as co-investigators on numerous other funded studies. Collaboration of Biometry personnel with AZCC investigators on the design, conduct, analysis, and interpretation of cancer studies continues to enhance the quality of the research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023074-35
Application #
8540960
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
35
Fiscal Year
2013
Total Cost
$315,719
Indirect Cost
$107,682
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Bea, Jennifer W; Jurutka, Peter W; Hibler, Elizabeth A et al. (2015) Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism 64:447-59
Leung, Sarah J; Rice, Photini S; Barton, Jennifer K (2015) In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis. Lasers Surg Med 47:40-9
Dickinson, Sally E; Rusche, Jadrian J; Bec, Sergiu L et al. (2015) The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog 54:1513-20
Quintero-Ramos, A; GutiƩrrez-Rubio, S A; Del Toro-Arreola, A et al. (2014) Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population. Genet Mol Res 13:8749-56
Landowski, Terry H; Gard, Jaime; Pond, Erika et al. (2014) Targeting integrin ?6 stimulates curative-type bone metastasis lesions in a xenograft model. Mol Cancer Ther 13:1558-66
Jiang, Yanlong; Kong, Qingke; Roland, Kenneth L et al. (2014) Membrane vesicles of Clostridium perfringens type A strains induce innate and adaptive immunity. Int J Med Microbiol 304:431-43
Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45
Kang, Hyun-Jin; Kendrick, Samantha; Hecht, Sidney M et al. (2014) The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc 136:4172-85
Chow, H-H Sherry; Garland, Linda L; Heckman-Stoddard, Brandy M et al. (2014) A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med 12:223
Lancaster, Jordan J; Juneman, Elizabeth; Arnce, Sarah A et al. (2014) An electrically coupled tissue-engineered cardiomyocyte scaffold improves cardiac function in rats with chronic heart failure. J Heart Lung Transplant 33:438-45

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