Experimental Mouse Shared Resource (EMSR) The goal of the Experimental Mouse Shared Resource (EMSR) is to enhance the productivity and capabilities of Members of the University of Arizona Cancer Center (UACC) by providing access to in vivo models, including immunocompromised and genetically engineered mouse (GEM) models, and to provide comprehensive support of experimentation in rodents (mouse and rat). The EMSR is dedicated to effective and efficient service that allows UACC Members to avoid duplication of equipment and training that would occur without such a Resource and to ensure the reproducibility of technical interventions and provide the rigorous quality control required for informative analyses of animal studies. EMSR personnel process tissues and perform procedures for experimental endpoints, including gross pathologic examinations with cryopreservation of organs/tissues and preparation of tissues for microscopic examination for further analysis by other UACC Shared Resources. The EMSR is divided into two sections: 1) the GEM Production Unit which utilizes the University of Arizona's Genetically Engineered Mouse Modeling (GEMM) core to generate the GEMs through ?sequence-to-whiskers? services, and 2) the Rodent Experimentation Unit which provides ?whiskers-to-data? services. These two units are complimentary and interactive, sharing animals, techniques, equipment and reagents. The EMSR maintains two blanket protocols for GEM generation and pilot work. The Unit is in compliance with the University's Biosafety Committee rules and is GLP-certified.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023074-36
Application #
9149088
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
36
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Justiniano, Rebecca; Williams, Joshua D; Perer, Jessica et al. (2017) The B6 -vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis. Photochem Photobiol 93:990-998
Li, Qike; Schissler, A Grant; Gardeux, Vincent et al. (2017) N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes. BMC Med Genomics 10:27
Harris, Lauren N; Bauer, Margaret R; Wiley, Joshua F et al. (2017) Chronic and episodic stress predict physical symptom bother following breast cancer diagnosis. J Behav Med 40:875-885
Uhrlaub, Jennifer L; Smithey, Megan J; Nikolich-┼Żugich, Janko (2017) Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses. J Immunol 199:403-407
Justiniano, Rebecca; Perer, Jessica; Hua, Anh et al. (2017) A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin. Photochem Photobiol 93:1472-1482
Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1:
Sells, Earlphia; Pandey, Ritu; Chen, Hwudaurw et al. (2017) Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6. Neoplasia 19:396-411
Polley, D J; Mihara, K; Ramachandran, R et al. (2017) Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2. Clin Exp Allergy 47:946-960
Bungard, Dixie; Copple, Jacob S; Yan, Jing et al. (2017) Foldability of a Natural De Novo Evolved Protein. Structure 25:1687-1696.e4
Das, Lipsa; Anderson, Todd A; Gard, Jaime M C et al. (2017) Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells. J Cell Biochem 118:1038-1049

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